abstract |
An antibody or antigen-binding domain comprising a light chain and a heavy chain, wherein the heavy chain comprises an amino acid sequence that is at least about 80% identical to the amino acid sequence of SEQ ID NO: 53 as shown in Figure 9 and the light chain comprises an amino acid sequence that is at least about 80% identical to the amino acid sequence of SEQ ID NO: 45 as shown in Figure 5, where the antibody or binding domain The antigen selectively binds to human OPGbp with a dissociation constant of 1 nM or less and inhibits bone resorption |