http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2738604-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b9cb964a6f1290f7906e949c0dbe79e3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e2817954cd008bcd609a4c4eb49050be |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-00 |
| filingDate | 2017-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-01-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b3f2eeff11444429be5b1443a043eef3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5dac559bf7788a7694204a55469b0c62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cda8b06dd34a0de128ca36945432ddb0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d2e44dd897c796892bc86f82a3f200eb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8d7d38ab7bac37ab306279137ed639d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bd3eadb3cabe02cbbd01858561066167 |
| publicationDate | 2020-01-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2738604-T3 |
| titleOfInvention | Improved preparation of streptoccocus pneumoniae type 3 vaccines |
| abstract | A synthetic method comprising the following steps: a) Provide a disaccharide of formula 2 ** Formula ** wherein Nap represents the 2-naphthylmethyl group, R1 represents an orthogonal protecting group stable to oxidation and stable to acid, R2 represents a Oxidation stable and acid stable orthogonal protecting group, R3 is an aryl or alkyl group, and X represents -OAc or -SR5, with R5 selected from -Me, -Et, -Pr, -Bu, -Ph and -Tol ; and a saccharide of formula 3 ** Formula ** wherein R1 represents an oxidation stable and acid stable orthogonal protecting group, R2 represents an oxidation stable and acid stable orthogonal protecting group, R3 is an aryl or alkyl group , W represents -LP or -Bn, P is -NR'R "or -N3, R 'and R" represent independently of each other -Bn, -Cbz, -Alilo or R' and R "together form phthaloyl, L represents - (CH2) n- or -C2H4-O-C2H4-, n is an integer selected from 2, 3, 4, 5, 6, 7, 8, 9 and 10, r is 1, 2 or 3; b) coupling of the disaccharide of formula 2 with the saccharide of formula 3 in the presence of a catalyst to obtain a saccharide of formula 1 ** Formula ** where Nap represents the 2-naphthylmethyl group, R1 represents an orthogonal protecting group stable to oxidation and stable to acid, R2 represents an oxidation stable and acid stable orthogonal protecting group, R3 is an aryl or alkyl group, W represents -LP or -Bn, P is -NR'R "or -N3, R 'and R" repres independently of each other -Bn, -Cbz, -Allyl or R 'and R "together form phthaloyl, L represents - (CH2) n- or -C2H4-O-C2H4-, n is an integer selected from 2, 3, 4, 5, 6, 7, 8, 9, and 10, and r is 1, 2, or 3. |
| priorityDate | 2016-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 135.