http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2737696-T3
Outgoing Links
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|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_05a203d85ee01909eaf728dc16f0f6cb |
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| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4725 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 2015-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0a623f36b266554b737520d8841b26f4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fa2a79327745a98005ae22ae504f5a61 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_86644adef04877f470858eb0dd4e836f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5b11e5e81f02b90a1c9d79410c2514d8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1cd804c5a49e7869de829585b4944c59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ac39ee4b9e488561894c3ff23c235374 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b6617f8d3e0ddda0dc53d719ee5a1a50 |
| publicationDate | 2020-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2737696-T3 |
| titleOfInvention | Pyrazolopyridines and pyrazolopyrimidines |
| abstract | A compound having the structure: ** Formula ** or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of said compound or pharmaceutically acceptable salt, in which: A, A "and A '" are independently C or N , where C may be unsubstituted or substituted by halo or C1-C6 alkyl; R1 is H, cyano or halo; R2 and R2 'are independently H, C1-C6 alkyl, cyano, C1-C6 alkoxy, C1-C6 alkylthio or C3-C8 cycloalkyl in which the alkyl, alkoxy or cycloalkyl is optionally substituted with one or more fluorine atoms; R3 is H, C1-C4 alkyl, phenyl, naphthyl, heteroaryl or 6-membered heterocyclic containing 1-3 N atoms, a 5-membered heteroaryl or heterocyclic containing (a) 1-4 N atoms or (b) 1 O or S atom and 0-3 N atoms, a 10-membered bicyclic heteroaryl or bicyclic containing 1-4 N atoms, a 9-membered heteroaryl or bicyclic heterocyclic containing (a) 1-4 N atoms or (b) 1 O or S atom and 0-3 N atoms, or an 8-membered heterocyl or bicyclic heterocyclic containing (a) 1-4 N atoms or (b) 1 O or S atom and 1 -3 N atoms or (c) 2 O or S atoms and 0-2 N atoms; wherein each of said phenyl, naphthyl, heteroaryl or heterocyclic is optionally substituted with alkyl, 1 -Y-R4 substituent and / or 1-4 substituents each independently selected from R5; Y is a bond, - (CH2) m- or -O-; R4 is (a) H, C1-C6 alkyl, C3-C8 cycloalkyl, halo, oxo, -OR6, -NR7R8, -SR6, -SOR9, -SO2R9, -COR6, -OCOR6, -COOR6, -NR6COR6, - CONR7R8, -NR6SO2R9, -SO2NR7R8, -NR6CONR7R8, -NR6COOR9 and -NR6SO2NR7R8; (b) phenyl or naphthyl, said phenyl and naphthyl are optionally substituted with 1-5 substituents selected from C1-C6 alkyl, C3-C8 cycloalkyl, halo, -CN, -OR6, -NR7R8, -SR6, -SOR9, -SO2R9 , -COR6, -OCOR6, - COOR6, -NR6COR6, -CONR7R8, -NR6SO2R9, -SO2NR7R8, -NR6CONR7R8, -NR6COOR9 and -NR6SO2NR7R8; or (c) a 3-8 membered saturated or partially unsaturated monocyclic heteroaryl, containing 1 or 2 heteroatoms selected from O and N, said heteroaryl is optionally substituted with 1-5 substituents selected from C1-C6 alkyl, C3-C8 cycloalkyl , halo, oxo, -OR6, -NR7R8, -SR6, -SOR9, -SO2R9, -COR6, - OCOR6, -COOR6, -NR6COR6, -CONR7R8, -NR6SO2R9, -SO2NR7R8, -NR6CONR7R8, -NR6OR -NR6OR -NR6OR R5 is C1-C6 alkyl, C3-C8 cycloalkyl, halo, -CN, -OR6, -NR7R8, -SR6, -SOR9, -SO2R9, -COR6, -OCOR6, - COOR6, -NR6COR6, -CONR7R8, -NR6SO2R9, -SO2NR7R8, -NR6CONR7R8, -NR6COOR9 or -NR6SO2NR7R8; R6 is H, C1-C6 alkyl or C3-C8 cycloalkyl, said C1-C6 alkyl is optionally substituted with -NR7R8 or a 3- to 8-membered saturated or partially unsaturated monocyclic heteroaryl, containing 1 or 2 heteroatoms selected from O and N , said heteroaryl is optionally substituted with 1-5 substituents selected from C1-C6 alkyl, C3-C8 cycloalkyl, halo, hydroxy and cyano; R7 and R8 are each independently H, C1-C6 alkyl or C3-C8 cycloalkyl or are taken together with the nitrogen atom to which they are attached to form a saturated 4-, 5- or 6-membered heterocyclic ring containing 1-2 atoms of nitrogen or 1 nitrogen and 1 oxygen atom, said C1-C6 alkyl is optionally substituted with C3-C8 cycloalkyl, halo, hydroxy, amino, (C1-C6 alkyl) amino or di (C1-C6 alkyl) amino and said heterocyclic ring is optionally substituted with one or more C1-C6 alkyl or C3-C8 cycloalkyl groups; R9 is C1-C6 alkyl or C3-C8 cycloalkyl; R10 is -NHSO2-R ', -NR "SO2-R' or SR 'where R' and R" are independently hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, phenyl, amino, C1-C6 alkylamino, di (alkyl C1-C6) amino, heterocyclic, - (CH2) n-W ', where W' is hydroxy, C3-C8 cycloalkyl, phenyl, naphthyl, heterocyclic, 5- or 6-membered heteroaryl containing 1-3 N atoms and / or O wherein each of said alkyl, cycloalkyl, heterocyclic, phenyl, naphthyl or heteroaryl may be unsubstituted or substituted by phenyl, heteroaryl, heterocyclic, halo, cyano, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, aryloxy , -SO2-R ', -NHSO2-R', -NR "SO2-R 'or SR' where R 'and R" are independently phenyl, C1-C6 alkyl or C3-C8 cycloalkyl; R11 and R12 are each independently H, hydroxy, halo, cyano, C1-C6 alkyl or C3-C8 cycloalkyl; y, m and n are independently 0, 1, 2 or 3. |
| priorityDate | 2014-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 839.