| abstract |
A compound of Formula I: ** Formula ** or a pharmaceutically acceptable salt thereof, wherein: R1 is optionally substituted C1-C10 alkyl, optionally substituted C1-C10 heteroalkyl, optionally substituted C3-C10 cycloalkyl, 3 to heterocycloalkyl Optionally substituted 18 elements, optionally substituted C6-C10 aryl or optionally substituted 5 to 18 element heteroaryl; R2 is nitro, cyano, halo, optionally substituted C1-C10 alkyl, optionally substituted C1-C10 heteroalkyl, optionally substituted C2-C10 alkynyl, or optionally substituted C2-C10 alkenyl; R3 is hydrogen, hydroxy or amino; each R4 is independently selected from the group consisting of hydrogen, halo, optionally substituted C1-C10 alkyl, optionally substituted C1-C10 heteroalkyl, and optionally substituted C3-C10 cycloalkyl, or two R4 groups and the carbon atom to which they are attached form cycloalkyl Optionally substituted C3-C8 or optionally substituted C5-C8 heterocycloalkyl; R5 is O or NR6, where R6 is selected from the group consisting of hydrogen, optionally substituted C1-C10 alkyl, and cyano; R7 is hydrogen, deuterium or optionally substituted C1-C10 alkyl, or R3 and R7 in combination form oxo; and n is 1 or 2; wherein the optional substituents that are present on each optionally substituted group are independently selected from: C1-C4 alkyl, C1-C4 heteroalkyl, C3-C10 cycloalkyl, 3-18 element heterocycloalkyl, C6-C10 aryl, 5-18 heteroaryl elements, hydroxyl, C1-C4 alkoxy, cyano, halo, ester, C1-C4 fluoroalkyl, C1-C4 alkylamino and amino. |