| abstract |
Use of at least one viscous compound, whose viscosity is higher Pa.s1, to substantially avoid degradation of a sensitive substance contained in a stable powdery composition, said sensitive substance being subjected to less than 20% degradation when said stable powdery composition is subject to temperatures of 60 ° C to 100 ° C and / or pressures of 2,106 to 107 Pa and / or a relative humidity of 60% to 100% during the granulation stage of said composition, wherein said powdery composition containing particles comprises: - a core containing said sensitive substance, at least one viscous compound as impregnating agent of the sensitive substance, and at least one support for the sensitive substance, and - a core coating, which is coated with at least one compound viscous as adhesion agent, where said viscous compounds are chosen from carboxymethyl cellulose (CMC), and the viscosity is measured using a BR viscometer OOKFIELD model LVDV-E equipped with a coaxial cylinder system, using the mobile device number 18 or 31 according to viscosities, in a temperature controlled measurement chamber with the help of a thermostatic bath, where these measurements are carried out at 20 ° C for 10% aqueous solutions of dry extract of the viscous compound, at different mobile rotation speeds of 10 to 100 rpm, the viscosity values detected being values obtained at the highest rotation speeds by integrating the limit values of torque (80% maximum) of the device. |