http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2733644-T3
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_42dcb8afd289e295b65f450020cbfdb4 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D513-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D407-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D497-04 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N43-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44 |
filingDate | 2013-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2019-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_608ed5a6668bee519765cada6e3f624b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_44c2a3c9ff02503ff79596637430068e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7b34aea3cc446c7847c4e23270f6b057 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e7010b56bad6fa8f22dd8aa21041abb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e7fe1d6afdaa74ee2fc0ddbc0dcabccd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_55e6382069e49bf4a51716f8918958df http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ebdd39ea9e31fc1fb2409586168ccb6d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0305f8f652cccd3608c4c6092fb88235 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f5a54632cdf77370aa09830644c0497b |
publicationDate | 2019-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | ES-2733644-T3 |
titleOfInvention | Compounds to treat spinal muscular atrophy |
abstract | A compound according to formula (Ia1): ** Formula ** or a free acid, free base, salt, isotopologist, stereoisomer, racemate, enantiomer, diastereomer or its tautomer, wherein: R1 is heterocyclyl selected from azetidin-1-yl , tetrahydrofuran-3-yl, pyrrolidin-1-yl, piperidin-1-yl, piperidin-4-yl, piperazin-1-yl, 1,4-diazepan-1-yl, 1,2,5,6-tetrahydropyridine -5-yl, 1,2,3,6-tetrahydropyridin-4-yl, hexahydropyrrolo [3,4b] pyrrole-1 (2H) -yl, (3aS, 6aS) -hexahydropyrrolo [3,4-b] pyrrole- 1 (2H) -yl, (3aS, 6aS) - hexahydropyrrolo [3,4-b] pyrrol-5 (1 H) -yl, (3aR, 6aR) -hexahydropyrrolo [3,4-b] pyrrole-5 (1H ) -yl, hexahydropyrrolo [3,4-c] pyrrole-2 (1H) -yl, (3aR, 6aS) -hexahydropyrrolo [3,4-c] pyrrole-2 (1H) -yl, octahydro-5H-pyrrolo [ 3,2-c] pyridin-5-yl, octahydro-6H-pyrrolo [3,4-b] pyridin-6-yl, (4aR, 7aR) -octahydro-6H-pyrrolo [3,4-b] pyridin-6- ilo, (4aS, 7aS) -octahydro-6H-pyrrolo [3,4- b] pyridin-6-yl, hexahydropyrrolo [1,2-a] pyrazin-6 (2H) -one, hexahydropyrrolo [1,2-a ] pyrazin-2 (1H) -yl, (7R, 8aS) - hexahydropyrr olo [1,2-a] pyrazin-2 (1H) -yl, (8aS) -hexahydropyrrolo [1,2-a] pyrazin-2 (1H) -yl, (8aR) -hexahydropyrrolo [1,2- a] pyrazin-2 (1H) -yl, (8aS) -octahydropyrrolo [1,2-a] pyrazin-2 (1H) -yl, (8aR) -octahydropyrrolo [1,2-a] pyrazin-2 (1H) -yl , octahydro-2H-pyrido [1,2-a] pyrazin-2-yl, 3-azabicyclo [3.1.0] hex-3-yl, 8-azabicyclo [3.2.1] oct-3-yl, (1 R , 5S) -8- azabicyclo [3.2.1] oct-3-yl, 8-azabicyclo [3.2.1] oct-2-en-3-yl, (1R, 5S) -8-azabicyclo [3.2.1] oct-2-en-3-yl, 9- azabicyclo [3.3.1] non-3-yl, (1R, 5S) -9-azabicyclo [3.3.1] non-3-yl, 2,5-diazabicyclo [ 2.2.1] hept-2-yl, (1S, 4S) -2,5-diazabicyclo [2.2.1] hept-2-yl, 2,5-diazabicyclo [2.2.2] oct-2-yl, 3, 8-diazabicyclo [3.2.1] oct-3-yl, (1R, 5S) -3,8- diazabicyclo [3.2.1] oct-3-yl, 1,4-diazabicyclo [3.2.2] non-4- ilo, azaspiro [3.3] hept-2-yl, 2,6-diazaspiro [3.3] hept-2-yl, 2,7-diazaspiro [3.5] non-7-yl, 5,8-diazaspiro [3.5] non- 8-yl, 2,7-diazaspiro [4.4] non-2-yl or 6,9-diazaspiro [4.5] dec-9-yl; wherein each case of heterocyclyl is optionally substituted with one, two or three R3 substituents; R2 is phenyl or heteroaryl selected from thien-2-yl, thien-3-yl, 1H-pyrazol-3-yl, 1H-pyrazol-4-yl, 1H-pyrazol-5-yl, 1Himidazol-1-yl, 1H -imidazol-4-yl, 1,3-thiazol-2-yl, 1,2,4-oxadiazol-3-yl, 1,3,4-oxadiazol-2-yl, pyridin-2-yl, pyridin-3 -yl, pyridin-4-yl, pyrimidin-4-yl, 1H-indole-3-yl, 1H-indole-4-yl, 1H-indole-5-yl, 1H-indole-6-yl, 1H-indazole -5-yl, 2H-indazol-5- yl, indolizin-2-yl, benzofuran-2-yl, benzofuran-5-yl, benzothien-2-yl, benzothien-3-yl, 1H-benzimidazol-2-yl , 1Hbenzimidazol-6-yl, 1,3-benzoxazol-2-yl, 1,3-benzoxazol-5-yl, 1,3-benzoxazol-6-yl, 1,3-benzothiazol-2-yl, 1,3 - benzothiazol-5-yl, 1,3-benzothiazol-6-yl, 9H-purin-8-yl, furo [3,2-b] pyridin-2-yl, furo [3,2-c] pyridin-2 -yl, furo [2,3-c] pyridin-2-yl, thieno [3,2-c] pyridin-2-yl, thieno [2,3-d] pyrimidin-6-yl, 1H-pyrrolo [2 , 3-b] pyridin-5-yl, 1H-pyrrolo [2,3-c] pyridin-4-yl, pyrrolo [1,2-a] pyrimidin-7-yl, pyrrolo [1,2-a] pyrazin -7-yl, pyrrolo [1,2-b] pyridazin-2-yl, pyrazolo [1,5-a] pyridin-2-yl, pyrazolo [1,5-a] pyrazin-2-yl, imidazo [1,2-a] pyridin-2-yl, imidazo [1,2-a] pyridin-6-yl, imidazo [1,2-a] pyrimidin -2-yl, imidazo [1,2-a] pyrimidin-6-yl, imidazo [1,2-c] pyrimidin-2-yl, imidazo [1,2-b] pyridazin-2-yl, imidazo [1 , 2-a] pyrazin-2-yl, imidazo [2,1-b] [1,3] thiazol-6-yl, imidazo [2,1-b] [1,3,4] thiadiazol-6-yl , [1,3] oxazolo [4,5-b] pyridin-2-yl or quinoxalin-2-yl; wherein each case of phenyl or heteroaryl is optionally substituted with one, two or three R6 substituents; Ra is hydrogen; Rb is hydrogen; R3 is selected, in each case, independently of cyano, halogen, hydroxy, oxo, C1-8 alkyl, halo- C1-8 alkyl, C1-8 alkylcarbonyl, C1-8 alkoxy, halo- C1-8 alkoxy, alkoxy C1-8-C1-8 alkyl, C1-8 alkoxycarbonyl, amino, C1-8 alkyl, (C1-8 alkyl) 2-amino, amino- C1-8 alkyl, C1-8 alkyl-amino-alkyl C1-8, (C1-8 alkyl) 2-amino-C1-8 alkyl, amino C1-8-alkyl, C1-8-amino-C1-8-alkyl-amino, (C1-8-amino alkyl C1-8 alkyl) 2-amino, (C1-8 alkyl) 2-amino-C1-8 alkyl-amino, [(C1-8 alkyl) 2-amino-C1-8 alkyl] 2-amino, (C1- alkyl 8-amino-C1-8 alkyl) (C1-8 alkyl) amino, [(C1-8 alkyl) 2-amino-C1-8 alkyl] (C1-8 alkyl) amino, C1-8 alkoxy-C1-8 alkyl -amino, (C 1-8 alkoxy-C 1-8 alkyl) 2-amino, (C 1-8 alkoxy-C 1-8 alkyl) (C 1-8 alkyl) amino, C 1-8 alkylcarbonyl amino, C 1-8 alkoxy -carbonyl-amino, hydroxy-C1-8 alkyl, hydroxy-C1-8 alkoxy-C1-8 alkyl, hydroxy-C1-8-alkyl, (hydroxy-C1-8 alkyl) 2-amino or (hydroxy-C1-alkyl -8) (C1-8 alkyl) amino; and R6 is selected, in each case, independently of halogen, hydroxy, cyano, nitro, C1-8 alkyl, C2-8 alkenyl, halo- C1-8 alkyl, hydroxy-C1-8 alkyl, C1-8 alkoxy, halo- C 1-8 alkoxy, C 1-8 alkoxy-C 1-8 alkyl, amino, C 1-8 alkyl, (C 1-8 alkyl) 2-amino or C 1-8 alkylthio. |
priorityDate | 2012-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 621.