http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2733131-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_238a0cbb4d846151b3a4844bad7f9879 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-538 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-522 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-34 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-538 |
| filingDate | 2010-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a5856de2d76e927c01f75243f53120a2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_93224291e8a3c3568a481975b13f5890 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_44f5c6b6f9f28342242c2a5cf03573dd |
| publicationDate | 2019-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2733131-T3 |
| titleOfInvention | Purine derivatives useful as hsp90 inhibitors |
| abstract | A compound of the formula: ** Formula ** in which (a) each of Z1, Z2 and Z3 is N; (b) Xa, Xb and Xc are all carbon, connected by two single bonds or a single link and a double link; (c) Y is -CH2- or -S-; (d) X4 is hydrogen or halogen; and (e) X2 and R in combination are selected from the group consisting of: (i) X2 is halogen and R is primary amino-alkyl, a secondary or tertiary alkyl-amino-alkyl, in which the amine nitrogen it is substituted to satisfy valence, with the proviso that R is not a piperidine residue; and (ii) X2 is selected from the group consisting of alkyl, alkenyl, alkynyl, aryl, cycloalkyl, cycloalkenyl, saturated or unsaturated heterocycle, aryl, aryloxy, alkoxy, halogenated alkoxy, alkenyloxy, hydroxyalkyl, amino, alkylamino, dialkylamino, acylamino , carbamyl, amido, dialkylamido, alkylamido, alkylsulfonamido, sulfonamido, trihalocarbon, -thioalkyl, SO2-alkyl, -COO-alkyl, OH or alkyl-CN, or part of a ring formed by R, and R is (a) hydrogen; or (b) C1 to C10 straight or branched chain alkyl, C2 to C6 alkenyl or C2 to C6 alkynyl, which is unsubstituted or substituted; or (c) aryl, heteroaryl, heterocyclic, cycloalkyl, alkylaryl or arylalkyl, which is unsubstituted or substituted; or (d) -SR71, -S (O) R71, -SO2R71, -OR71, -COOR71, -CONR71R72, -CN, -R7AOR7B, -R7ANR7B, -R7ANR71R7B, -R7ASR7B, - R7AS (O) R7B, -R7ASO2R7B7B7R7B , -NR71R72, -OSO2N (R7c) 2, -N (R7c) SO2OH, -N (R7c) SO2R7c, -R7AOSO2N (R7C) 2 or - R7AN (R7C) OSO2R7C, where each R71 and R72 is independently selected from group consisting of hydrogen, COOR7B, CON (R7C) 2, C1 to C6 alkyl, C2 to C6 alkenyl, C2 to C6 alkynyl, -R7AOR7B, -R7ANR7B, -R7ASR7B, - R7AS (O) R7B, -R7ASO2R7B, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkylaryl, arylalkyl, alkylheteroaryl and heteroarylalkyl, each R7A is independently C1 to C6 alkyl, C2 to C6 alkenyl, C2 to C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkylaryl or each alkyl is independently hydrogen, C1 to C6 alkyl, C2 to C6 alkenyl, C2 to C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkylaryl, arylalkyl, alkylheteroaryl, heteroarylalkyl, -SO2OH, -SO2N (R7A) 2, -SO2NHR7A or -SO2N2H2 ; and each R7C is independently hydrogen, C1 to C6 alkyl, C2 to C6 alkenyl, C2 to C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkylaryl, arylalkyl, alkylheteroaryl or heteroarylalkyl, in which "alkyl" refers to a saturated hydrocarbon optionally substituted, linear, cyclic or branched, in which the atom directly attached to the central structure is a carbon atom; "alkenyl" refers to an optionally substituted linear, cyclic or branched hydrocarbon having at least one double bond, in which the atom directly attached to the central structure is a carbon atom; "alkynyl" refers to an optionally substituted linear, cyclic or branched hydrocarbon having at least one triple bond, in which the atom directly attached to the central structure is a carbon atom; "aryl" refers to any optionally substituted group obtained from a simple aromatic ring, including heteroaryl; "aryloxy" refers to an aryl group that is connected to the central structure through an oxygen atom; "amino" refers to any optionally substituted group consisting of a nitrogen linked by simple bonds to carbon or hydrogen atoms; and "heterocyclic" refers to an optionally substituted moiety containing at least one carbon atom and at least one atom of a non-carbon element within a ring structure. |
| priorityDate | 2009-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 479.