http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2732735-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ac409458365ff9d5dc07bf78b39ea951 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y301-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y301-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-902 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-907 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-22 |
| filingDate | 2008-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f348239a53aee36918562afa5d46ede6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_904947291fad0eabcbadb362eb0e827e |
| publicationDate | 2019-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2732735-T3 |
| titleOfInvention | Single-chain meganucleases designed rationally with non-palindromic recognition sequences |
| abstract | A recombinant single-chain meganuclease comprising: (a) a first LAGLIDADG subunit comprising a polypeptide sequence having at least 85% sequence identity with residues 9-151 of a wild-type I-CreI meganuclease of SEQ ID NO: 1 and which has a first recognition semisite; and (b) a second LAGLIDADG subunit comprising a polypeptide sequence having at least 85% sequence identity with residues 9-151 of a wild-type I-CreI meganuclease of SEQ ID NO: 1 and having a second recognition semisite; wherein said first and second LAGLIDADG subunits are covalently linked by a polypeptide linker; wherein said polypeptide linker comprises 23-56 residues; wherein said first subunit is covalently linked to said polypeptide linker in a moiety corresponding to a position selected from the group consisting of positions 142-163 of SEQ ID NO: 1; wherein said second subunit is covalently linked to said polypeptide linker in a moiety corresponding to a position selected from the group consisting of positions 1-9 of SEQ ID NO: 1; and wherein said first and second LAGLIDADG subunits are able to act together to recognize and cleave a non-palindromic DNA sequence that is a hybrid of said first recognition semisite and said second recognition semisite. |
| priorityDate | 2007-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 363.