http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2731823-T3
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d2276405ae0e23cfcd15651de21c8565 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-497 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-454 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-454 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 |
filingDate | 2014-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2019-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5b3f1757e5ec84195affc6e2a66497d4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_173b3a93210927187f486867fbf23acc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eeebfb946778977356a46c64505e88ef http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1313999ffab4b47863602f1c70f203ec http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b6d2a93172194870d7cfcfdf78d53017 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_afdae939be2d4b65640c648b845a5461 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b91816a0a1fde8ff67317a03cf584cb5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8d47790160a92cfdc6c2dcfa19e589b |
publicationDate | 2019-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | ES-2731823-T3 |
titleOfInvention | Amide derivatives for the GPR119 agonist |
abstract | An amide derivative, its stereoisomers or pharmaceutically acceptable salts, wherein the amide derivative is: a) an amide derivative of the formula 1: ** Formula ** in which: X1, X2, X3, X4, X5, × 6 'X7 and X8 are each independently C or N; R1 is -F or -C1-3 perfluorinated alkyl; both R2 and R3 are independently selected from the group consisting of a halogen, -C1-5alkyl and C3-6cycloalkyl, in which the -C1-5alkyl and the C3-6cycloalkyl, each independently, may not be substituted or substituted with a halogen, -CN, -OC1-5alkyl or -C1-5alkyl, or R2 and R3, together with the carbon atom to which they are attached, can form a C3-6cycloalkyl (in which the C3-6cycloalkyl may not be substituted or substituted with a halogen, -OC1-5alkyl or -C1-5alkyl); R4 and R5 are each independently H, halogen or -C1-5alkyl; R6 and R7 are each independently H, halogen, -C1-5alkyl or -CN; R8 is methyl; R9 is H, halogen or OH; and m is 1 or 2; or b) selected from the group consisting of: (2S, 4R) -1- (2'-cyano-3-fluoro-4 '- ((1- (2-fluoro-2-methylpropyl) piperidine-4-yl ) methoxy) biphenylcarbonyl) -4-hydroxypyrrolidine-2-carboxamide; (2S, 4S) -1- (2'-cyano-3-fluoro-4 '- ((1- (2-fluoro-2-methylpropyl) piperidine-4-yl) methoxy) biphenylcarbonyl) -4-fluoropyrrolidine-2 -carboxamide; (2S, 4S) -4-fluoro-1- (4 '- ((1 - ((1- (trifluoromethyl) cyclobutyl) methyl) piperidine-4-yl) methoxy) biphenylcarboxylatenyl) pyrrolidine-2-carboxamide; (2S, 4R) -4-hydroxy-1- (4 '- ((1 - ((1- (trifluoromethyl) cyclobutyl) methyl) piperidine-4-yl) methoxy) biphenylcarbonyl) pyrrolidine-2-carboxamide; (2S, 4R) -1- (2-fluoro-4- (5 - ((1 - ((1- (trifluoromethyl) cyclobutyl) methyl) piperidine-4-yl) methoxy) pyrazine-2-yl) benzoyl) - 4- hydroxypyrrolidine-2-carboxamide; (2S, 4R) -1- (4 '- ((1- (2-ethyl-2-fluorobutyl) piperidine-4-yl) methoxy) biphenylcarbonyl) -4-hydroxypyrrolidine-2-carboxamide; (2S, 4R) -1- (4 '- ((1- (2-ethyl-2-fluorobutyl) piperidine-4-yl) methoxy) -2-fluorobiphenylcarbonyl) -4-hydroxypyrrolidine-2-carboxamide; (2S, 4R) -1- (2-fluoro-4- (6 - ((1- (3,3,3-trifluoro-2,2-dimethylpropyl) piperidine-4-yl) methoxy) pyridine-3-yl ) benzoyl) -4-hydroxypyrrolidine-2-carboxamide; (2S, 4S) -4-fluoro-1- (4- (5 - ((1 - ((1- (trifluoromethyl) cyclobutyl) methyl) piperidine-4-yl) methoxy) pyrazine-2-yl) benzoyl) pyrrolidine - 2-carboxamide; (2S, 4S) -1- (4 '- ((1- (2-ethyl-2-fluorobutyl) piperidine-4-yl) methoxy) -2-fluorobiphenylcarbonyl) -4-fluoropyrrolidine-2-carboxamide; (2S, 4S) -1- (4 '- ((1- (2-ethyl-2-fluorobutyl) piperidine-4-yl) methoxy) -3-fluorobiphenylcarbonyl) -4-fluoropyrrolidine-2-carboxamide; (2S, 3S) -1- (2-fluoro-4 '- ((1 - ((1- (trifluoromethyl) cyclobutyl) methyl) piperidine-4-yl) methoxy) biphenylcarbonyl) -3-hydroxypyrrolidine-2-carboxamide; (2S, 3S) -1- (2'-cyano-4 '- ((1- (2-ethyl-2-fluorobutyl) piperidine-4-yl) methoxy) -3-fluorobiphenylcarbonyl) -3-hydroxypyrrolidine-2- carboxamide; (2S, 3S) -1- (3-fluoro-4- (6 - ((1 - ((1- (trifluoromethyl) cyclobutyl) methyl) piperidine-4-yl) methoxy) pyridine-3-yl) benzoyl) - 3- hydroxypyrrolidine-2-carboxamide; 20 (S) -1- (4- (6 - ((1- (2,2-difluorobutyl) piperidine-4-yl) methoxy) pyridine-3-yl) -2-fluorobenzoyl) pyrrolidine-2-carboxamide; (S) -1- (3-fluoro-4 '- ((1- (2,2,3,3,3-pentafluoropropyl) piperidine-4-yl) methoxy) biphenylcarbonyl) pyrrolidine-2-carboxamide; (2S, 4R) -1- (2 ', 3-difluoro-4' - ((1- (3,3,3-trifluoro-2,2-dimethylpropyl) piperidine-4-yl) methoxy) biphenylcarbonyl) -4 - hydroxypyrrolidine-2-carboxamide; (2S, 4R) -1- (4- (6 - ((1- (2,2-difluorobutyl) piperidine-4-yl) methoxy) pyridine-3-yl) -2-fluorobenzoyl) -4-hydroxypyrrolidine-2 - carboxamide; (2S, 3S) -1- (4 '- ((1- (2-ethyl-2-fluorobutyl) piperidine-4-yl) methoxy) -3,3'-difluorobiphenylcarbonyl) -3-hydroxypyrrolidine-2-carboxamide; (2S, 3S) -1- (4 '- ((1- (2-ethyl-2-fluorobutyl) piperidine-4-yl) methoxy) -2'-fluorobiphenylcarbonyl) -3-hydroxypyrrolidine-2-carboxamide; (2S, 3S) -1- (2-fluoro-4- (5 - ((1 - ((1- (trifluoromethyl) cyclobutyl) methyl) piperidine-4-yl) methoxy) pyrazine-2-yl) benzoyl) - 3- hydroxypyrrolidine-2-carboxamide; (2S, 3S) -1- (3-fluoro-4- (5 - ((1 - ((1- (trifluoromethyl) cyclobutyl) methyl) piperidine-4-yl) methoxy) pyrazine-2-yl) benzoyl) - 3- hydroxypyrrolidine-2-carboxamide; (2S, 4R) -1- (2-fluoro-4 '- ((1 - ((1-trifluoromethyl) cyclobutyl) methyl) piperidine-4-yl) methoxy) biphenylcarbonyl-4-hydroxypyrrolidine-2-carboxamide; (2S, 4R) -1- (3-fluoro-4 '- ((1- (2,2,3,3,3-pentafluoropropyl) piperidine-4-yl) methoxy) biphenylcarbonyl) -4-hydroxypyrrolidine-2- carboxamide; (2S, 4R) -1- (4- (5 - ((1- (2-ethyl-2-fluorobutyl) piperidine-4-yl) methoxy) pyrimidine-2-yl) -2-fluorobenzoyl) -4-hydroxypyrrolidine -2-carboxamide; (2S, 4R) -1- (3'-cyano-3-fluoro-4 '- ((1- (2-fluoro-2-methylpropyl) piperidine-4-yl) methoxy) biphenylcarbonyl) -4-hydroxypyrrolidine-2 -carboxamide; 1- (2-Fluoro-4- (5 - ((1 - ((1- (trifluoromethyl) cyclobutyl) methyl) piperidine-4-yl) methoxy) pyrazine-2-yl) benzoyl) -4-hydroxypiperidine-2- carboxamide; (S) -1- (2-fluoro-4- (5 - ((1- (2,2,3,3,3-pentafluoropropyl) piperidine-4-yl) methoxy) pyridine-2-yl) benzoyl) pyrrolidine -2-carboxamide; (2S, 4R) -1- (2-fluoro-4- (5 - ((1- (2,2,3,3,3-pentafluoropropyl) piperidine-4-yl) methoxy) pyridine-2-yl) benzoyl ) -4- hydroxypyrrolidine-2-carboxamide; (S) -1- (2-fluoro-4- (5 - ((1- (3,3,3-trifluoro-2,2-dimethylpropyl) piperidine-4-yl) methoxy) pyridine-2-yl) benzoyl ) pyrrolidine-2-carboxamide; (2S, 4R) -1- (2-fluoro-4- (5 - ((1- (3,3,3-trifluoro-2,2-dimethylpropyl) piperidine-4-yl) methoxy) pyridine-2-yl ) benzoyl) -4-hydroxypyrrolidine-2-carboxamide; (2S, 4R) -1- (3'-cyano-4 '- ((1- (2-ethyl-2-fluorobutyl) piperidine-4-yl) methoxy) -3-fluorobiphenylcarbonyl) -4-hydroxypyrrolidine-2- carboxamide; (2S, 4R) -1- (4- (5 - ((1- (2-ethyl-2-fluorobutyl) piperidine-4-yl) methoxy) pyridine-2-yl) -2-fluorobenzoyl) -4-hydroxypyrrolidine -2-carboxamide; (2S, 4R) -1- (2-fluoro-4- (5 - ((1 - ((1- (trifluoromethyl) cyclobutyl) methyl) piperidine-4-yl) methoxy) pyridine-2-yl) benzoyl) - 4- hydroxypyrrolidine-2-carboxamide; (2S, 4R) -4-hydroxy-1- (4- (5 - ((1- (2,2,3,3,3-pentafluoropropyl) piperidine-4-yl) methoxy) pyrazine-2-yl) benzoyl ) pyrrolidine-2-carboxamide; (2S, 4R) -1- (3-fluoro-4- (5 - ((1 - ((1- (trifluoromethyl) cyclobutyl) methyl) piperidine-4-yl) methoxy) pyridine-2-yl) benzoyl) - 4- hydroxypyrrolidine-2-carboxamide; (2S, 4R) -1- (4- (5 - ((1- (2-ethyl-2-fluorobutyl) piperidine-4-yl) methoxy) pyridine-2-yl) -3-fluorobenzoyl) -4-hydroxypyrrolidine -2-carboxamide; (2S, 4R) -1- (3'-cyano-4 '- ((1- (2-fluoro-2-methylpropyl) piperidine-4-yl) methoxy) biphenylcarbonyl) -4-hydroxypyrrolidine-2-carboxamide; (S) -1- (2-fluoro-4- (5 - ((1 - ((1- (trifluoromethyl) cyclobutyl) methyl) piperidine-4-yl) methoxy) pyridine-2-yl) benzoyl) pyrrolidine-2 - carboxamide; (2S, 4R) -1- (4- (5 - ((1- (2-ethyl-2-fluorobutyl) piperidine-4-yl) methoxy) pyridine-2-yl) benzoyl) -4-hydroxypyrrolidine-2- carboxamide; (2S, 4R) -1- (4- (6 - ((1- (2-ethyl-2-fluorobutyl) piperidine-4-yl) methoxy) pyridine-3-yl) benzoyl) -4-hydroxypyrrolidine-2- carboxamide; (2S, 4R) -1- (4- (6 - ((1- (2-ethyl-2-fluorobutyl) piperidine-4-yl) methoxy) pyridine-3-yl) -3-fluorobenzoyl) -4-hydroxypyrrolidine -2-carboxamide; (2S, 4R) -1- (4- (6 - ((1- (2-ethyl-2-fluorobutyl) piperidine-4-yl) methoxy) pyridine-3-yl) -2-fluorobenzoyl) -4-hydroxypyrrolidine -2-carboxamide; (2S, 4R) -1- (3-fluoro-4- (5 - ((1- (2,2,3,3,3-pentafluoropropyl) piperidine-4-yl) methoxy) pyridine-2-yl) benzoyl ) -4- hydroxypyrrolidine-2-carboxamide; (S) -1- (3-fluoro-4- (5 - ((1- (2,2,3,3,3-pentafluoropropyl) piperidine-4-yl) methoxy) pyridine-2-yl) benzoyl) pyrrolidine -2-carboxamide; (S) -1- (3-fluoro-4- (5 - ((1 - ((1- (trifluoromethyl) cyclobutyl) methyl) piperidine-4-yl) methoxy) pyridine-2-yl) benzoyl) pyrrolidine-2 - carboxamide; (2S, 4R) -1- (3-fluoro-4- (6 - ((1 - ((1- (trifluoromethyl) cyclobutyl) methyl) piperidine-4-yl) methoxy) pyridine-3-yl) benzoyl) - 4- hydroxypyrrolidine-2-carboxamide; (2S, 4R) -1- (2-fluoro-4- (6 - ((1 - ((1- (trifluoromethyl) cyclobutyl) methyl) piperidine-4-yl) methoxy) pyridine-3-yl) benzoyl) - 4- hydroxypyrrolidine-2-carboxamide; (2R, 4R) -1- (4 '- ((1- (2-ethyl-2-fluorobutyl) piperidine-4-yl) methoxy) -2-fluorobiphenylcarbonyl) -4-hydroxypyrrolidine-2-carboxamide; (2S, 4R) -4-hydroxy-1- (4- (5 - ((1- (3,3,3-trifluoro-2,2-dimethylpropyl) piperidine-4-yl) methoxy) pyridine-2-yl ) benzoyl) pyrrolidine-2-carboxamide; and (2S, 4R) -1- (3-fluoro-4- (5 - ((1- (3,3,3-trifluoro-2,2-dimethylpropyl) piperidine-4-yl) methoxy) pyridine-2- il) benzoyl) -4-hydroxypyrrolidine-2-carboxamide. |
priorityDate | 2013-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
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