http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2730757-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_40765ca9a78b54a8a76f781d159ad145 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-428 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D261-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-428 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D261-08 |
| filingDate | 2015-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_67d0dd6cc49e9e36d9fc873751b03251 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a780b4880836943b176786804230904 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_37c742c706e1c4eac71d47809f55e716 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ee1d9b228e5bf46dc7f4e7e28a6d9ef6 |
| publicationDate | 2019-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2730757-T3 |
| titleOfInvention | FXR modulating compounds containing hydroxyls (NR1H4) |
| abstract | A compound according to the following Formula (1), a pharmaceutically acceptable enantiomer, diastereomer, tautomer, solvate or salt thereof ** Formula ** in which R is selected from the group consisting of hydrogen, halogen, -C1-alkyl -6, C2-6 alkenyl, C2-6 alkynyl, - halo C1-6alkyl, -C0-6-R7-alkylene, -O-C0-6-R7-alkylene, -C0-6-CN-alkylene, -C0-6 -alkylene -NR7R8, O-C3-10-cycloalkyl, O-C1-6-R7-alkylene, O-heterocycloalkyl- C3-10-, -C0-6-C2-alkylene, -C0-6-C (O) R7-alkylene, - alkylene C0-6- C (O) NR7R8, -alkylene C0-6-C (O) NR7SO2R7, -alkylene C0-6-N (R7) C (O) R7, -alkylene C0-6-SOx-R7, - alkylene C0-6-SO3H, -alkylene C0-6-SO2-NR7R8, -alkylene C0-6-SO2-NR8COR7, -alkylene C0-6-N (R7) SO2-R8, and -alkylene C0-6-SO2- heterocycloalkyl C3-10, wherein alkylene, cycloalkyl, heterocycloalkyl and 5- or 6-membered heteroaryl are unsubstituted or substituted by 1 to 4 substituents independently selected from the group consisting of halogen, CN, -C1-3alkyl, -C1-3haloalkyl, OH, oxo, CO2H, SO3H, -O-C1-3alkyl and O-C1-3alkyl; R7 is independently selected from the group consisting of hydrogen, -C1-6alkyl, -haloC1-6alkyl, CO-6-alkylene-C3-8cycloalkyl, -C0-6alkyl-C3-8-heterocycloalkyl, heteroaryl of 5 or 6-membered and phenyl, wherein alkyl, alkylene, cycloalkyl, heterocycloalkyl, phenyl, and heteroaryl are unsubstituted or substituted with 1 to 6 substituents independently selected from the group consisting of halogen, CN, OH, oxo, CO2H-C1-alkyl -3, -3-3 -haloalkyl, O-C1-3-alkyl, O-C1-3-haloalkyl, SO3H and SO2-C1-3-alkyl; R8 is independently selected from the group consisting of hydrogen, -C1-6alkyl, -haloC1-6alkyl and -C3-6cycloalkyl; or R7 and R8, when taken together with the nitrogen atom to which they are attached, can complete a 3-8 membered ring, containing carbon atoms and optionally containing 1 or 2 heteroatoms selected from O, S or N, in wherein the ring is unsubstituted or optionally substituted with 1 to 4 substituents independently selected from the group consisting of fluorine, OH, oxo, C1-4alkyl, and C1-4alkyl-halo; A is a 6-10 membered monocyclic or bicyclic aryl or a 5-10 membered monocyclic or bicyclic heteroaryl containing 1 to 5 heteroatoms independently selected from the group consisting of N, O, and S, wherein the aryl and the Heteroaryl are unsubstituted or substituted with one or two groups selected independently from the group consisting of OH, halogen, CN, O-C1-6alkyl, O-haloC1-6alkyl, -C1-6alkyl, -haloC1-6alkyl, C3-6 cycloalkyl, C5-6-heterocycloalkyl and halo-C3-6-cycloalkyl; Q is a C3-10 cycloalkyl ring, or a C5-10 cycloalkyl ring of the bridging type in which the -OCH2-Z substituent is not directly adjacent to the A substituent, where when Q is a bicyclic or multicyclic ring system , a carbon atom can be optionally substituted by an oxygen, SOx or NR7; Z is selected from ** Formula ** where L is selected from the group consisting of a bond, -C1-3alkylene and alkylene-O-C1-3; Y is selected from the group consisting of phenyl, pyridyl, -pyridyl -N-oxide, pyrimidyl, pyridinonyl, pyrimidinonyl, -C4-8 cycloalkyl and -heterocycloalkyl-C4-8, wherein phenyl, pyridyl, -N-pyridyl oxide , pyrimidyl, pyridinonyl, pyrimidinonyl, -C4-8 cycloalkyl and -C4-8 heterocycloalkyl are substituted with R2 and R3 and optionally substituted once or twice with a group selected from fluorine, chlorine, CN, NH2, NH (-C1-alkyl) 3), N (-C1-3alkyl) 2, -C1-3alkyl, fluoroC1-3alkyl, OH, -C1-3alkoxy, -fluoroalkoxy C1-3, -C3-6 cycloalkyl and C3-6 fluorocycloalkyl; R1 is selected from the group consisting of -C1-4alkyl and -C3-6cycloalkyl, wherein -C1-4alkyl is unsubstituted or substituted with 1 to 3 substituents independently selected from the group consisting of fluorine, hydroxy, -C1-3alkoxy and fluoroalkoxy C1-3, and -C3-6 cycloalkyl is unsubstituted or substituted with 1 to 3 substituents independently selected from the group consisting of fluorine, hydroxy, -C1-3alkyl, fluoroC1-3alkyl, -C1-3alkoxy and fluoroalkoxy C1-3; R2 and R3 are independently selected from the group consisting of hydrogen, halogen, -C1-3alkyl, -haloC1-3alkyl, -C1-3alkoxy, haloC1-3alkoxy, cyclopropyl and fluorocyclopropyl; R4 is independently selected from the group consisting of halogen, -C1-3alkyl, -haloC1-3alkyl, -C1-3alkoxy, haloC1-3alkoxy, C3-6cycloalkyl, -C1-3alkylene-O-C1-alkyl -3 and fluoro-C3-6 cycloalkyl; R5 is selected from the group consisting of hydrogen, fluorine, CH3, CHF2, and CF3; n is selected from 0, 1, 2, 3 and 4; x is independently selected from 0, 1 and 2. |
| priorityDate | 2014-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 934.