| abstract |
Cyclohexenone compound of the following formula (I): ** Formula ** wherein each of X and Y is independently oxygen, NR5 or sulfur; R is a hydrogen or C (= O) -C1-C8-alkyl; R1, R2 and R3 are each independently a hydrogen, methyl or (CH2) m-CH3; R4 is NR5R6, OR5, OC (= O) R7, C (= O) OR5, C (= O) R5, C (= O) NR5R6, halogen, 5- or 6-membered lactone, C1-C8 alkyl, C2 alkenyl -C8, C2-C8 alkynyl, aryl, glucosyl, wherein the 5 or 6 membered lactone, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, aryl and glucosyl are optionally substituted with one or more selected substituents NR5R6, OR5, OC (= O) R7, C (= O) OR5, C (= O) R5, C (= O) NR5R6, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3 cycloalkyl -C8 and C1-C8 haloalkyl; R5 and R6 are each independently hydrogen or C1-C8 alkyl; R7 is C1-C8-alkyl, OR5 or NR5R6; m = 1-12; and n = 1-12; or a pharmaceutically acceptable salt or solvate thereof, for use in the treatment, inhibition, and / or prevention of fatty liver disease. |