http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2730405-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fd9210a3ea9c393abdee0903e12c128f http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4500bc7f9251b4869af20965162f0f94 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1272 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1278 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-475 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-475 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127 |
| filingDate | 2013-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9839b98b06a3adb7e0273f6d916b8a8a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a13063f5df28dfa30677ca258270176 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b20584ce8a80685ba53db6c0a0adfef9 |
| publicationDate | 2019-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2730405-T3 |
| titleOfInvention | Improved method for the preparation of vincristine encapsulated in liposomes for therapeutic use |
| abstract | A method of preparing a pharmaceutically acceptable liquid composition comprising liposome-encapsulated vincristine that is free from substantial degradation products, the method comprising: (a) reconstituting in a single vial (i) a first solution comprising vincristine sulfate in a concentration from 1 mg / ml to 5 mg / ml, where the first solution has a pH of 3.5 to 5.5; and (ii) a second solution comprising sphingomyelin / cholesterol liposomes at a low pH; (b) raising the pH of the reconstitutive solution in the individual vial to a pH of 7.0 to 7.5; (c) heating the individual vial comprising the reconstitutive solution in a balanced dry thermoblock at 75 ° C for at least 13 to 18 minutes, wherein said thermoblock comprises one or more holes 1-5% greater than the length or diameter means of the individual vial to produce a reconstituted liposome encapsulated vincristine solution; and (d) equilibrate the reconstituted solution to room temperature. |
| priorityDate | 2012-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 70.