| abstract |
Compound represented by formula I: ** Formula ** in which X is NH or S; R1 is selected from the group consisting of C (O) (CR5R6) dN (R4) 2, C (O) N = S (O) R5R6, (CR5R6) dC (O) (CR5R6) dR4, (CR5R6) dC ( O) (CR5R6) dOR4 and (CR5R6) dC (O) (CR5R6) dN (R4) 2, in which each R4 is independently selected from the group consisting of hydrogen, hydroxyl, C1-C8 alkyl, C1-C8 hydroxyalkyl, (CR5R6) d and N (R4) 2 can form a 3- to 7-membered heterocyclic ring, including aziridine, azetidine, pyrrolidine, 5-fluoropyrrolidine, piperidine, 6-fluoropiperidine, N-methylpiperazine, morpholine, 2,6-dimethylmorpholine, thiomorpholine , and wherein said heterocyclic ring may be optionally substituted with up to three of R5; wherein R5 and R6 are independently selected from the group consisting of hydrogen, halo, hydroxyl, C1-C8 alkyl, C1-C8 hydroxyalkyl, C1-C8 alkoxyalkyl, alkoxycarbonylalkyl and alkoxycarbonyl; a is 0 or an integer from 1 to 3; d is 0; b is 0; Y is selected from the group consisting of: (1 ') - (CH2) g-O- (CH2) h-; (2 ') - (CH2) g-NR1- (CH2) h-; (3 ') - (CH2) g-S (O) n- (CH2) h-; and (18 ') a single link; where g is 0; h is 0; n is 0; R1 is independently selected from the group consisting of hydrogen, CF3, alkyl and hydroxyalkyl; ring A is ** Formula ** (i) phenyl; RIII optionally represents 1-3 substituents independently selected from the group consisting of C1-C5 linear or branched alkyl, halogen, cyano and nitro; Z is selected from the group consisting of (1 ') (CH2) iN (R7) C (O) N (R8) (CH2) j (2') (CH2) iN (R7) C (O); and (3 ') C (O) N (R8) (CH2) j; in which: i is 0; j is 0; R7 and R8 are independently selected from the group consisting of hydrogen and alkyl; Ring B is ** Formula ** which is selected from the group consisting of: ** Formula ** and ** Formula ** in which n is 0; RIV optionally represents 1-3 substituents, independently selected from the group consisting of alkoxy, alkyl, cyano, halo, haloalkoxy, haloalkyl, hydroxyl, hydroxyalkyl and nitro; and including any pharmaceutically acceptable salt. |