| abstract |
A composition comprising a modified antisense oligonucleotide consisting of 12-30 linked nucleosides, of which at least a portion of the 12 nucleobase sequence is complementary to the nucleotides present within a selected region of nucleotides 1388-1423, 1394-1423 and 1399-1423 of SEQ ID NO: 9, or a salt or ester thereof, for use in the treatment of a keloid, or to prevent the formation, reformation, or growth of a keloid after skin injury , in a subject in need, wherein the composition is administered to the subject by one or more injections of threading at the site of the keloid or skin lesion, in an amount effective to treat, or to prevent formation, reformation or growth of the keloid, in which the effective amount is 0.1 to 50 mg of the modified oligonucleotide by injection per linear centimeter of the keloid or the skin lesion. |