http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2729643-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf32b60391b469c41e86c353437f5751 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-40 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-542 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6849 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6803 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-646 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-1133 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-64 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-54 |
| filingDate | 2014-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b102f0f5e8f80a6ccd88aaa1e46c851b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_903019e59536d8ed9ebdbc8b5c0abf4b |
| publicationDate | 2019-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2729643-T3 |
| titleOfInvention | Methods for conjugation of oxime with ketone modified polypeptides |
| abstract | A method for converting a ketone modified polypeptide into an oxime modified polypeptide, wherein the method comprises contacting the ketone modified polypeptide with a group of formula RO-NH2 in the presence of an amine promoter and at a polypeptide concentration. of at least 1 mg / ml, in which the group of formula RO-NH2 is a compound of formula H2N-OL-PL, where L represents a linker and PL represents a loading group and in which the ketone modified polypeptide it is prepared by converting a polypeptide comprising a reducible disulfide bond into a ketone modified polypeptide comprising a group of formula [PP] -S-CH2-C (= O) -CH2-S- [PP], where each S is a sulfur of the disulfide bond, and [PP] indicates the place where the ends of the linker group are attached to the polypeptide, wherein the method comprises forming a mixture of a polypeptide containing a reducible disulfide bond, an aqueous buffer and 1,3- dihaloacetone, then add a reducing agent that can reduce the disulfide bond. |
| priorityDate | 2013-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 244.