http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2728201-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c59e4659957948d8d1de37010d7e0c3e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-551 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 2015-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_705d306100eedcef1c513610b8ac7014 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a468dc96505cd4edbd2152a582a0e4b3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e424554ef61b1ce73f0e380d0216edf6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_af5bed59980603026038bf9f767063d2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_46240547007dae9fa01eff13c971048d |
| publicationDate | 2019-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2728201-T3 |
| titleOfInvention | Mnk inhibitors and related methods |
| abstract | A compound according to Formula (I): ** Formula ** or a stereoisomer, tautomer or a pharmaceutically acceptable salt thereof, wherein: W1 and W2 are independently O, S or N-OR ', where R' it is C1-C4 alkyl; Y is -N (R5) -, -O-, -S-, -C (O) -, -S = O, -S (O) 2- or -CHR9-; R1 is hydrogen, lower alkyl, cycloalkyl or heterocyclyl, where any C1-C4 alkyl, cycloalkyl or heterocyclyl is optionally substituted with 1, 2 or 3 J groups; n is 1, 2 or 3; R2 and R3 are each independently hydrogen, alkyl, alkenyl, alkynyl, aryl, aralkylene, heteroaryl, heteroarylalkylene, cycloalkyl, cycloalkylalkylene, heterocyclyl or heterocyclylalkylene, where any alkyl, aryl, aralkylene, heteroaryl, heteroarylalkylene, cycloalkyl, heteroalkyl, heteroalkyl, heteroalkyl, heteroalkyl, heteroalkyl, heteroalkyl, heteroalkyl, heteroalkyl, cycloalkyl, heteroalkyl, heteroalkyl, cycloalkyl, heteroalkyl, heteroalkyl, cycloalkyl, heteroalkyl, cycloalkyl, heteroalkyl, heteroalkyl, cycloalkyl, heteroalkyl, heteroalkyl heterocyclylalkylene, is optionally substituted with 1, 2 or 3 J groups; or R2 and R3 taken together with the carbon atom to which they are attached form a cycloalkyl or heterocyclyl, where any cycloalkyl or heterocyclyl is optionally substituted with 1, 2 or 3 J groups; R4a and R4b are each independently hydrogen, halogen, hydroxyl, thiol, hydroxyalkylene, cyano, alkyl, alkoxy, acyl, thioalkyl, alkenyl, alkynyl, cycloalkyl, aryl or heterocyclyl; R5 is hydrogen, cyano or C1-C4 alkyl; or R5 and R8 taken together with the atoms to which they are attached form a condensed heterocyclyl optionally substituted with 1, 2 or 3 J groups; R6, R7 and R8 are each independently hydrogen, hydroxy, halogen, cyano, amino, alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, cycloalkylalkylene, cycloalkylalkylene, alkylaminyl, alkylcarbonylamino, cycloalkylcarbonylaminyl, cycloalkylamino, heterocyclyl, heteroaryl, heteroaryl, heteroaryl, heteroaryl, heteroaryl, heteroaryl, anyoaryl, heteroaryl, heteroaryl, heteroaryl, heteroaryl, heteroaryl, yylalkyl amino, alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, cycloalkylalkylene, cycloalkylalkylene, amino, alkylaminyl, alkylcarbonylamino, cycloalkylcarbonylamino, cycloalkylamino, heterocyclylamino, heteroaryl, or heterocyclyl optionally substituted with 1, 2 or 3 J groups; or R7 and R8 taken together with the atoms to which they are attached form a condensed heterocyclyl or heteroaryl optionally substituted with 1, 2 or 3 J groups; J is -SH, -SR9, -S (O) R9, -S (O) 2R9, -S (O) NH2, -S (O) NR9R9, -NH2, -NR9R9, -COOH, -C (O) OR9, -C (O) R9, -C (O) -NH2, -C (O) -NR9R9, hydroxy, cyano, halogen, acetyl, alkyl, lower alkyl, alkenyl, alkynyl, alkoxy, haloalkyl, thioalkyl, cyanoalkylene, alkylamino, NH2-C (O) -alkylene, NR9R9-C (O) -alkylene, -CHR9-C (O) -alkyl, -C (O) -alkyl, alkylcarbonylamino, cycloalkyl, cycloalkylalkylene, cycloalkylalkylene, cycloalkylcarbonylamino, cycloalkylamino, -CHR9-C (O) -cycloalkyl, -C (O) -cycloalkyl, -CHR9-C (O) -aryl, -CHR9-aryl, -C (O) -aryl, -CHR9-C (O) -heterocycloalkyl, -C (O) -heterocycloalkyl, heterocyclylaminyl or heterocyclyl; or any two J groups attached to the same carbon or heteroatom can be taken together to form oxo; and R9 is hydrogen, C1-C4 alkyl or -OH. |
| priorityDate | 2014-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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