http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2725200-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c447b57ce1103219f0e4583b3ca9319a |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y301-06013 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-92 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-565 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2869 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 |
| filingDate | 2010-10-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d75b338153c190a959ead2907aaa047 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8647f499b6c69198268711ca512dd107 |
| publicationDate | 2019-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2725200-T3 |
| titleOfInvention | Methods and compositions to increase the activity of iduronate 2-sulfatase in the CNS |
| abstract | A fusion antibody comprising: (a) a fusion protein comprising the amino acid sequences of an immunoglobulin heavy chain and an iduronate-2-sulfatase (IDS), wherein the amino acid sequence of the iduronate-2-sulfatase is covalently linked to the carboxyl end of the amino acid sequence of the immunoglobulin heavy chain; and (b) an immunoglobulin light chain; wherein the fusion antibody crosses the blood-brain barrier (BHE) by binding to an insulin receptor and can catalyze the lysosomal removal of sulfate groups from the sulfated alpha-L-iduronic acid unit of glycosaminoglycans dermatan sulfate, heparan sulfate and heparin, wherein the immunoglobulin heavy chain is an IgG immunoglobulin heavy chain, and wherein the IDS amino acid sequence comprises the amino acid sequence of SEQ ID NO: 9, and where the light chain amino acid sequence of immunoglobulin comprises SEQ ID NO: 8 and wherein the amino acid sequence of the immunoglobulin heavy chain comprises SEQ ID NO: 7. |
| priorityDate | 2009-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 274.