http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2724581-T3
Outgoing Links
| Predicate | Object |
|---|---|
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| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-501 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-245 |
| filingDate | 2014-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3bd85a495c71097a00a828d4c28959d8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_98f3324ba9bbf8794d6915a40655fba1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_61c6d9d83bd78e9e1e5ba1cdf381cfc2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2bf183cccae2f9eacc6e850ba2ed7d50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_459c56e050acaa931eda83f4b42d6578 |
| publicationDate | 2019-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2724581-T3 |
| titleOfInvention | Pyridazinone compounds and uses thereof |
| abstract | A compound of formula (I), or a pharmaceutically acceptable salt thereof: in which: ** Formula ** G1 is selected from the group consisting of and R5; G2 is hydrogen, halogen, -CN, an optionally substituted C1-6 alkyl, an optionally substituted aryl, an optionally substituted heteroaryl, -CH2OH, -CH (Y1) (OH) or -C (O) Y1; G3 is selected from the group consisting of hydrogen, -C (O) Y2, -C (O) O-Y2, - (CH2) -OC (O) Y2, - (CH2) -OC (O) OY2, - ( CHCH3) -OC (O) Y2 and - (CHCH3) -OC (O) OY2; Y1 and Y2 are independently an optionally substituted C1-6 alkyl or an optionally substituted aryl; R1 is selected from the group consisting of OR6, NH2, an optionally substituted alkyl, an optionally substituted aryl, an optionally substituted monosubstituted amine, an optionally substituted disubstituted amine, an optionally substituted heterocyclyl, an optionally substituted N-sulfonamido and an optionally substituted alkoxyamine , or R1 is R10; R2 is hydrogen, C1-6 alkyl, an optionally substituted C3-6 cycloalkyl, an optionally substituted aryl, an optionally substituted aryl (C1-6 alkyl) or an optionally substituted C-amido; R3 is hydrogen or C1-6 alkyl; or R2 and R3 are taken together with the carbon to which they are attached to form an optionally substituted C3-6 cycloalkyl or an optionally substituted 5-6 membered heterocyclyl, or R2 and R3 are taken together to form = O; R4 is selected from the group consisting of an optionally substituted aryl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heteroaryl and an optionally substituted heterocyclyl; or R4 is A1RA4RB4, in which A1 is CH or N; and RA4 and RB4 are each independently an optionally substituted phenyl; R5 is selected from the group consisting of an optionally substituted aryl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heteroaryl and an optionally substituted heterocyclyl; R6 is selected from the group consisting of hydrogen, C1-6 alkyl, -C (O) R7 and -C (O) NR8R9; R7 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, heteroaryl, heterocyclyl, aryl (C1-6 alkyl), heteroaryl (C1-6 alkyl) and heterocyclyl (C1-6 alkyl ); and R8 and R9 are independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, heteroaryl, heterocyclyl, aryl (C1-6 alkyl), heteroaryl (C1-6 alkyl) and heterocyclyl ( C1-6 alkyl); or R8 and R9 are taken together with the nitrogen to which they are attached to form an optionally substituted heterocyclyl; in which when R1 is R10, then R10 and R4 are taken together and include L1, in which L1 connects R10 and R4 to form a ring of 11 to 20 members, or in which when R1 is R10, then R10 and R5 they are taken together and include L1, in which L1 connects R10 and R5 to form a ring of 11 to 20 members; R10 is an optionally substituted -CH2-, an optionally substituted -CH = CH-, O (oxygen), S (sulfur) or NR11; R11 is hydrogen or C1-6 alkyl; L1 is -L2- or -L3-L4-L5-; L2 is selected from the group consisting of an optionally substituted alkylene, an optionally substituted alkenylene, an optionally substituted heteroalkylene and an optionally substituted heteroalkenylene; L3 is an optionally substituted C1-6 alkylene; L4 10 is an optionally substituted cycloalkyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted heterocyclyl, O (oxygen), S (sulfur) or NR11; and L5 is an optionally substituted C1-6 alkylene or an optionally substituted heteroalkylene; and Z1 and Z2 are independently 0, 1, 2, 3 or 4. |
| priorityDate | 2013-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 948.