http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2722924-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3e6c3a8a43fb0c64c528087df3244584 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-24 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2863 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-103 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-645 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-641 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-08 |
| filingDate | 2013-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_571b9c4bbe78d868009b4abafddb0915 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2088b1a0e499d663a7625ca67702b0aa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_48a5b92e6f681b318aad890e3ce89006 |
| publicationDate | 2019-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2722924-T3 |
| titleOfInvention | Conjugates of multivalent cell penetration proteins and peptides and their uses |
| abstract | A conjugate comprising a protein, and one or more multivalent cell penetration peptides (multivalent CPPs) each multivalent CPP comprising at least two cell penetration peptides (CPP), wherein the multivalent CPP (s) are covalently bound to the protein, wherein each of the multivalent CPP (s) is a dendrimer of cell penetration peptides (cell penetration peptide dendrimer, dCPP) comprising a core of the dendrimer and at least two cell penetration peptides (CPP), which are coupled to the core of the dendrimer, said core of the dendrimer is a core of the peptide dendrimer comprising lysines as branching points and one or more cysteines as one or more anchoring groups, and comprising or consisting of ** (See formula) ** or ** (See formula) ** in which K is Lys, A is Ala and C is Cys, in which the one or more cell penetration peptides comprise the amino acid sequence of penetrat ina (SEQ ID NO. 1), TAT (47-60) (transcription transactivator derived from human immunodeficiency virus, SEQ ID NO. 2), PreS2-TLM (translocation motive derived from the preS2 domain of hepatitis B virus, SEQ ID NO. 3), R9 (SEQ ID NO. 4), MTS (membrane translocation signal, SEQ ID NO. 5 ), SynB1 (CPP derived from synthetic porcine protegrin 1, SEQ ID NO. 6), pVEC (CPP derived from vascular endothelial cadherin, SEQ ID NO. 7), NLS (nuclear localization signal, SEQ ID NO. 8), or combinations thereof. |
| priorityDate | 2012-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 39.