http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2722425-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f52c68e4149a6c462b850d4e7cc2b2f9 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-79 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-81 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4418 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-81 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-79 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4433 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 |
| filingDate | 2015-09-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ad2087d7663b86d50eb25e54cde75988 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_26323334777905170455ed79c6b2d9dd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_58c15bd6c776f7cbf78f0abda5183b0d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e636abe018d267927fc22f94f4289c8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2089e70def808d6a3d5a9726a7edc42a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8f2dbf877b459d815d1fad415bcf505e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ecf3cc91fb15a67fd8f7042c310a42ac http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_70788d458f9986ec1c27bbce40e3c87c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3da3da99f183ae2356eaf99a547b4e2e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_be135d9c864bdddecaadbd81816b0e4c |
| publicationDate | 2019-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2722425-T3 |
| titleOfInvention | (2H) -2-Oxopyridines as inhibitors of factor XIa for the treatment of thrombotic diseases |
| abstract | Compound of formula ** (See formula) ** in which R1 represents a group of formula ** (See formula) ** in which * is the site of binding to the oxopyridine ring, R6 represents bromine, chlorine, fluorine, methyl, difluoromethyl, trifluoromethyl, methoxy, difluoromethoxy, trifluoromethoxy or methylamino, R7 represents bromine, chlorine, fluorine, cyano, nitro, hydroxy, methyl, difluoromethyl, trifluoromethyl, methoxy, ethoxy, difluoromethoxy, trifluoromethyl, 3,3 trifluoroprop-1-in-1-yl or cyclopropyl, R8 represents hydrogen, chlorine or fluorine, R2 represents hydrogen, bromine, chlorine, fluorine, cyano, C1-C3 alkyl, difluoromethyl, trifluoromethyl, 2,2 -difluoroethyl, 2,2,2-trifluoroethyl, C1-C3 alkoxy, difluoromethoxy, trifluoromethoxy, 1,1-difluoroethoxy, 2,2-difluoroethoxy, 2,2,2-trifluoroethoxy, methylcarbonyl or cyclopropyl, R3 represents hydrogen, C1-alkyl -C5, C1-C4 alkoxy, difluoromethyl, trifluoromethyl, 1,1-difluoroethyl, 1,1,2,2,2-pentadeuteroethyl, 3,3,3-trifluoro-2-hi droxiprop-1-yl, 3,3,3-trifluoro-2-methoxyprop-1-yl, 3,3,3-trifluoro-2-ethoxyprop-1-yl, prop-2-in-1-yl, cyclopropyloxy or cyclobutyloxy, in which alkyl may be substituted with a substituent selected from the group consisting of fluoro, cyano, hydroxy, difluoromethyl, trifluoromethyl, methoxy, ethoxy, difluoromethoxy, trifluoromethoxy, C3-C6 cycloalkyl, oxoheterocyclyl, 4 to 6 members, , 4-dioxanyl, oxazolyl, pyrazolyl, oxadiazolyl, dihydro-oxazolyl, phenyl and pyridyl, in which cycloalkyl can be substituted with 1 to 2 substituents independently of each other selected from the group consisting of fluoro, hydroxy, methyl, ethyl, methoxy , ethoxy, difluoromethyl, trifluoromethyl, difluoromethoxy, and trifluoromethoxy, and wherein oxo-heterocyclyl may be substituted with 1 to 2 substituents independently of one another selected from the group consisting of oxo, fluorine, methyl, ethyl, difluoromethyl and trifluoromethyl, and in the one that oxazolil or, pyrazolyl and oxadiazolyl may be substituted with 1 to 2 substituents independently of each other selected from the group consisting of methyl and ethyl, R4 represents hydrogen, R5 represents a group of formula ** (See formula) ** in which is the binding site to the nitrogen atom, R12 represents hydrogen or fluorine, R13 represents hydroxy or -NHR14, where R14 represents hydrogen or C1-C4 alkyl, or one of its salts, its solvates or the solvates of its salts. |
| priorityDate | 2014-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 65.