| abstract |
A long-acting insulin conjugate liquid formulation comprising a pharmaceutically effective amount of a long-acting insulin assembly, in which an insulin, which is a physiologically active peptide, binds to an Fc region of immunoglobulin; and a stabilizer devoid of albumin, in which the stabilizer comprises a buffer, a sugar alcohol, a non-ionic surfactant and an isotonic agent, in which: the buffer is acetate buffer having a pH between 5.6 and 7 , 0; the sugar alcohol is mannitol or sucrose; The nonionic surfactant is polysorbate having a concentration of 0.001 to 0.02% (w / v); and the isotonic agent is sodium chloride. |