| abstract |
3 - [(4S) -8-Bromo-1-methyl-6- (2-pyridinyl) -4H-imidazo [1,2-a] [1,4] benzodiazepin-4-yl] -propionic acid methyl ester (CNS7056) of formula (I) ** Formula ** or a pharmaceutically acceptable salt or solvate, for use in sedation, characterized in that CNS 7056 is administered in combination with an opioid, CNS 7056 is administered in a fixed dose of 2 at 10 mg, preferably between 3 and 10 mg, preferably between 3 and 9, and more preferably between 5 and 8 mg, the opioid is fentanyl or a salt or solvate thereof, and fentanyl is administered in a fixed dose of 50 at 200 mcg / patient, preferably 100 mcg / patient, in which the term "fixed dose" refers to an amount of a drug administered to a patient regardless of body weight. |