| abstract |
A compound represented by the following general formula (I), a pharmaceutically acceptable salt thereof, or a solvate thereof: ** Formula ** wherein R1 represents -NH (C = O) -V-R3, - (C = O ) NH-V-R3, or the following formula: ** Formula ** where V represents a single bond, methylene or -C (CH3) 2O-; R3 represents an optionally substituted C3-C6 alkyl group, a cross-linked cyclic hydrocarbon group, a fused polycyclic hydrocarbon group, an optionally substituted aryl group or an optionally substituted heterocyclic group; and R4 and R5 may be the same or different and independently represent a hydrogen atom, a halogen atom, a cyano group, an optionally substituted C1-C6 alkyl group, an optionally substituted C1-C6 alkoxy group, or R4 and R5 may be linked between yes and form an optionally substituted non-aromatic heterocyclic ring; R2 represents an acyl group, an optionally substituted C1-C6 alkyl group, an optionally substituted aryl group, or an optionally substituted heterocyclic group; X represents a hydrogen atom, an oxygen atom, a hydroxyl group, a methyl group, or a methylene group; A represents -NR6 -, - NHCONH -, - O-CH2-, or-S-CH2-; R6 represents a hydrogen atom or an optionally substituted C1-C6 alkyl group, or R6 and R2 can bond together and form an optionally substituted non-aromatic heterocyclic ring; n represents the number of methylene chains and represents an integer of 0, 1 or 2; and a doublet containing a dotted line represents a single bond or a double bond; provided that when A is -O-CH2- or-S-CH2-, R2 represents an optionally substituted aryl group, or an optionally substituted heterocyclic group |