http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2713681-T3
Outgoing Links
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| filingDate | 2015-01-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-05-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ce91780f4a4324baa712ff7971d78c6c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_507b8bc8ebf2a5f2fc0993b8ad767d88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6bd418c9d47f6edcf324c17c46401d7d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3686dcb070c70ffdaafb6d67d7c36d27 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e51b9e5ad3e6d1a8fd3c240b9ec7960 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7ddb44ba514100de7c721be69bb47dc3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0f5a6d6f2c231680372ef147992b9004 |
| publicationDate | 2019-05-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2713681-T3 |
| titleOfInvention | ROR modulators of carbocyclic sulfone gamma |
| abstract | The compound having the following formula (I): ** Formula ** or a stereoisomer or a pharmaceutically acceptable salt thereof, wherein: A is a 3, 4 or 5 membered cycloalkyl or cycloalkenyl ring; B is a phenyl ring; R1 and R1` are, independently in each case, hydrogen, halo, CF3, OCF3, CN, NO2, - (CH2) rOR1b, - (CH2) rS (O) pRb, - (CH2) rC (O) Rb, - (CH2) rC (O) ORb, - (CH2) rOC (O) Rb, - (CH2) rNR11R11, - (CH2) rC (O) NR11R11, - (CH2) rNRbC (O) Rc, - (CH2) rNRbC (O) ORc, -NRbC (O) NR11R11, -S (O) pNR11R11, -NRbS (O) pRc, C1-6 alkyl substituted with 0-3 R1a, C1-6 haloalkyl, C2-6 alkenyl substituted with 0- 3 Ra, C2-6 alkynyl substituted with 0-3 Ra, - (CH2) 3-14 membered r-carbocycle substituted with 0-3 Ra, or - (CH2) 5-7 membered r-heterocycle comprising atoms of carbon and 1-4 heteroatoms selected from N, O and S (O) p substituted with 0-3 Ra; R1a is, independently in each case, hydrogen, = O, halo, OCF3, CN, NO2, - (CH2) rORb, - (CH2) rS (O) pRb, - (CH2) rC (O) Rb, - (CH2 ) rC (O) ORb, - (CH2) rOC (O) Rb, (CH2) rNR11R11, - (CH2) rC (O) NR11R11, - (CH2) rNRbC (O) Rc, - (CH2) rNRbC (O) ORc, -NRbC (O) NR11R11, -S (O) pNR11R11, -NRbS (O) pRc, C1-6 alkyl substituted with 0-3 Ra, C1-6 haloalkyl, C2-6 alkenyl substituted with 0-3 Ra, C2-6 alkynyl substituted with 0-3 Ra, - (CH2) 3-14 membered r-carbocycle substituted with 0-3 Ra, or - (CH2) 5-7 membered r-heterocycle comprising carbon atoms and 1 -4 heteroatoms selected from N, O and S (O) p substituted with 0-3 Ra; R1b is, independently in each case, hydrogen, CF3, - (CH2) rORb, - (CH2) rS (O) pRb, - (CH2) rC (O) R1d, - (CH2) rC (O) ORb, - ( CH2) rOC (O) Rb, - (CH2) rNR11R11, - (CH2) rC (O) NR11R11, - (CH2) rNRbC (O) R1c, - (CH2) rNRbC (O) ORc, - (CH2) rNRbC ( O) NR11R11, - (CH2) rS (O) 2NR11R11, - (CH2) rNRbS (O) 2Rc, C1-6 alkyl substituted with 0-2 Ra, haloalkyl C1-6, - (CH2) r-carbocycle 3- 14 members substituted with 0-3 Ra, or - (CH2) 5-7 membered r-heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O and S (O) p substituted with 0-2 Ra; R2 is, independently in each case, hydrogen, C1-6 alkyl substituted with 0-3 R2a, = CR2aR2a, C2-6 alkenyl substituted with 0-3 R2a, - (CH2) rOR2b, - (CH2) rC (O) R2b , - (CH2) rC (O) OR2b, - (CH2) rOC (O) OR2b, - (CH2) rOC (O) NR11R11, - (CH2) rNR2bC (O) NR11R11, - (CH2) rC (O) NR11R11 , - (CH2) rNR2bC (O) R2c, - (CH2) rNR2bC (O) OR2c, - (CH2) rNR11R11, -30 NR2bS (O) pRc, - (CH2) rNR2bS (O) pNR11R11, - (CH2) r 3-10 membered carboxycycle substituted with 0-3 R2a or - (CH2) 4-10 membered r-heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O and S (O) p substituted with 0 -3 R2a; or an R2 together with an R2 in an adjacent carbon combine to form a condensed ring substituted with 0-3 R2a, wherein the condensed ring is selected from 3-10 membered carbocycle substituted with 0-3 R2a, or 3-heterocycle -7 members comprising carbon atoms and 1-4 heteroatoms selected from N, O and S (O) p substituted with 0-3 R2a; R2a is, independently in each case, hydrogen, = O, halo, OCF3, CN, NO2, - (CH2) rORb, - (CH2) rS (O) pRb, - (CH2) rC (O) Rb, - (CH2 ) rC (O) ORb, - (CH2) rOC (O) Rb, - (CH2) rNR11R11, - (CH2) rC (O) NR11R11, - (CH2) rNRbC (O) Rc, - (CH2) rNRbC (O ) ORc, -NRbC (O) NR11R11, -S (O) pNR11R11, -NRbS (O) pRc, C1-6 alkyl substituted with 0-3 Ra, C1-6 haloalkyl, C2-6 alkenyl substituted with 0-3 Ra , C2-6 alkynyl substituted with 0-3 Ra, - (CH2) 3-4 membered r-carbocycle substituted with 0-3 Ra, or - (CH2) 5-7 membered r-heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O and S (O) p substituted with 0-3 Ra; R2b is, independently in each case, hydrogen, CF3, - (CH2) rORb, - (CH2) rS (O) pRb, - (CH2) rC (O) R1d, - (CH2) rC (O) ORb, - ( CH2) rOC (O) Rb, - (CH2) rNR11R11, - (CH2) rC (O) NR11R11, - (CH2) rNRbC (O) R1c, - (CH2) rNRbC (O) ORc, - (CH2) rNRbC ( O) NR11R11, - (CH2) rS (O) 2NR11R11, - (CH2) rNRbS (O) 2Rc, C1-6 alkyl substituted with 0-2 Ra, haloalkyl C1-6, - (CH2) r-carbocycle 3- 14 members substituted with 0-3 Ra, or - (CH2) 5-7 membered r-heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O and S (O) p substituted with 0-2 Ra; R2c is, independently in each case, hydrogen, C1-6 alkyl substituted with 0-3 Ra, C2-6 alkenyl substituted with 0-3 Ra, C3-10 cycloalkyl substituted with 0-3 Ra, C6-10 aryl substituted with 0 -3 Ra, or - (CH2) r 5-10 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S (O) p, substituted with 0-3 Ra; R2d is, independently in each case, hydrogen, C1-6 alkyl substituted with 0-2 Rd, C1-6 haloalkyl, C (O) NR11R11, C3-6 cycloalkyl substituted with 0-2 Rd, or (CH2) r-phenyl substituted with 0-2 Ra, a 5-10 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S (O) p, substituted with 0-3 Ra; R3 is selected from hydrogen, halo, N3, CN, - (CH2) rOR3b, - (CH2) rNR11R11, C1-6 alkyl substituted with 0-3 R3a and C3-10 cycloalkyl substituted with 0-3 R3a; 4-10-membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O and S (O) p, substituted with 0-3 Ra, or together with the carbon atoms to which they are attached, an R3 it is combined with a second R3 located in an adjacent atom to form a 5-7 member carbocycle or a 5-7 member heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O and S (O) p, each optionally substituted with 0-3 R3a; R3a is, independently in each case, hydrogen, = O, halo, OCF3, OCHF2, CF3, CHF2, CN, NO2, - (CH2) rORb, - (CH2) rS (O) pRb, - (CH2) rC (O ) Rb, - (CH2) rC (O) ORb, - (CH2) rOC (O) Rb, - (CH2) rNR11R11, - (CH2) rC (O) NR11R11, - (CH2) rNRbC (O) Rc, - (CH2) rNRbC (O) ORc, -NRbC (O) NR11R11, -S (O) pNR11R11, -NRbS (O) pRc, C1-6 alkyl substituted with 0-3 Ra, C2-6 alkenyl substituted with 0-3 Ra, C2-6 alkynyl substituted with 0-3 Ra, C1-6 haloalkyl, - (CH2) 3-14 membered r-carbocycle substituted with 0-3 Ra, or a 5-10 (- CH2) r-heterocycle members comprising carbon atoms and 1-4 heteroatoms selected from N, O and S (O) p substituted with 0-3 Ra; R3b is, independently in each case, hydrogen, CF3, - (CH2) rORb, - (CH2) rS (O) pRb, - (CH2) rC (O) R1d, -10 (CH2) rC (O) ORb, - (CH2) rOC (O) Rb, - (CH2) rNR11R11, - (CH2) rC (O) NR11R11, - (CH2) rNRbC (O) R1c, - (CH2) rNRbC (O) ORc, - (CH2) rNRbC (O) NR11R11 1, - (CH2) rS (O) 2NR11R11, - (CH2) rNRbS (O) 2Rc, C1-6 alkyl substituted with 0-3 Ra, C1-6 haloalkyl, - (CH2) r-carbocycle 3-14 members substituted with 0-3 Ra, or - (CH2) 5-7 membered r-heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O and S (O) p substituted with 0-3 Ra; R11 is, independently in each case, hydrogen, C1-6 alkyl substituted with 0-3 Rd, CF3, C3-10 cycloalkyl substituted with 0-3 Rd, (CH) r-phenyl substituted with 0-3 Rd, or a - (CH2) 5-7 membered r-heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O and S (O) p substituted with 0-3 Rd; or, together with the nitrogen atom to which they are attached, an R11 is combined with a second R11 to form a 4-12 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S (O ) p substituted with 0-3 Rd; Ra is, independently in each case, hydrogen, = O, halo, OCF3, CF3, CHF2, CN, NO2, - (CH2) rORb, - (CH2) rS (O) pRb, - (CH2) rC (O) Rb , - (CH2) rC (O) ORb, - (CH2) rOC (O) Rb, - (CH2) rNR11R11, - (CH2) rC (O) NR11R11, - (CH2) rNRbC (O) Rc, - (CH2 ) rNRbC (O) ORc, -NRbC (O) NR11R11, -S (O) pNR11R11, -NRbS (O) pRc, C1-6 alkyl substituted with 0-3 Rf, C1-6 haloalkyl, C2-6 alkenyl substituted with 0-3 Rf, C2-6 alkynyl substituted with 0-3 Rf, - (CH2) 3-14 membered r-carbocycle substituted with 0-3 Rf, or a 5-7 membered (CH2) r-heterocycle which it comprises carbon atoms and 1-4 heteroatoms selected from N, O and S (O) p substituted with 0-3 Rf; Rb is, independently in each case, hydrogen, C1-6 alkyl substituted with 0-3 Rd, C1-6 haloalkyl, C2-6 alkenyl substituted with 0-3 Rd, C3-6 cycloalkyl substituted with 0-3 Rd, - ( CH2) 5-7 membered r-heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S (O) substituted with 0-3 Rf, or (CH2) 6-10 atoms r-carbocycle substituted with 0-3 Rd; Rc is, independently in each case, C1-6 alkyl substituted with 0-3 Rf, cycloalkyl (CH2) r-C3-6 substituted with 0-3 Rf, - (CH2) 5-7 membered r-heterocycle comprising atoms carbon and 1-4 heteroatoms selected from N, O, and S (O) p substituted with 0-3 Rf, or (CH2) r-phenyl substituted with 0-3 Rf; Rd is, independently in each case, hydrogen, = O, halo, OCF3, CF3, CN, NO2, -ORe, - (CH2) rC (O) Rc, -NReRe, -NReC (O) ORc, C (O) NReRe, -NReC (O) Rc, CO2Rc, -NReSO2Rc, SO2Rc, C1-6 alkyl substituted with 0-3 Rf, C3-6 cycloalkyl substituted with 0-3 Rf, (CH2) r-phenyl substituted with 0-3 Rf or - (CH2) -5-7-membered r-heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O and S (O) p substituted with 0-3 Rf; Re, independently in each case, is selected from hydrogen, C (O) NRfRf, C1-6 alkyl, C3-6 cycloalkyl or (CH2) r-phenyl substituted with 0-3 Rf; Rf is, independently in each case, hydrogen, = O, halo, CN, NH2, NH (C1-6 alkyl), N (C1-6 alkyl) 2, SO2 (C1-6 alkyl), CO2H, CO2 (C1 alkyl -6), OH, C3-6 cycloalkyl, CF3 or O (C1-6 alkyl); or Rf is, independently in each case, an optionally substituted 5-10 membered - (CH2) r-heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S (O), phenyl or C3 cycloalkyl -6, each group optionally substituted with 1-3 groups selected from halo, CN, CF3, C1-6 alkyl and O (C1-6 alkyl); q and n are independently selected from 0, 1, 2 and 3; p is 0, 1 or 2; and r is 0, 1, 2, 3 or 4. |
| priorityDate | 2014-01-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 583.