http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2713324-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b74452a889073845b47a40e23c273814 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D279-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C381-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C209-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C209-68 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D279-18 |
| filingDate | 2014-10-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b954a6ce82acb6b407d20a869b8a8fc6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_34bd4e6b73375d61f06f28db0d1fa4ff http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1e2b74bccd9bae8b49c14109c898141f |
| publicationDate | 2019-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2713324-T3 |
| titleOfInvention | Methods of chemical synthesis of diaminophenothiazinium compounds, including methylthioninium chloride (MTC) |
| abstract | A synthetic method comprising the steps of, in order: reduction of nitrosyl (NR), in which an N, N-disubstituted-3-optionally substituted-4-nitrosyl aniline, 2, is reduced to form said N, N -disubstituted-1,4-diamino-5-optionally substituted benzene, 3: ** Formula ** thiosulfonic acid formation (TSAF), in which an N, N-disubstituted-1,4-diamino-5-optionally benzene substituted, 3, is oxidized in the presence of a thiosulfate, preferably a thiosulfate, which is or comprises Na2S2O3, to provide said S- {2- (amino) -3- (optionally substituted) -5- (disubstituted amino) -phenyl } -thiosulfuric acid ester, 4: ** Formula ** oxidative coupling (OC), in which an S- {2- (amino) -3- (optionally substituted) -5- (disubstituted amino) -phenyl} ester of the thiosulfuric acid, 4, is oxidatively coupled to an N, N-disubstituted-3-optionally substituted aniline, 5, using an oxidizing agent that is or comprises Cr (VI), to provide an ammonium [4- {2- (thiosulfate) ) -4- (amino disu stituido) -6- (optionally substituted) -phenyl-imino} -3- (optionally substituted) - cyclohexa-2,5-dienyliden] -N, N-disubstituted, 6: ** Formula ** in which; each of R1 and R9 is independently selected from: -H; C1-4 alkyl; C2-4 alkenyl; and halogenated C1-4 alkyl; each of R3NA and R3NB is independently selected from: C1-4 alkyl; C2-4 alkenyl; and halogenated C1-4 alkyl; each of R7NA and R7NB is independently selected from: C1-4 alkyl; C2-4 alkenyl; and halogenated C1-4 alkyl; and, in which the steps of nitrosyl reduction (NR), thiosulfonic acid formation (TSAF) and oxidative coupling (OC) are completed in a single reaction vessel; and, wherein said reduction in said nitrosyl (NR) reduction step is by reaction with a reducing agent that is or comprises Fe (O). |
| priorityDate | 2013-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 26.