| abstract |
A compound of formula IA having the structure: ** Formula ** or a pharmaceutically acceptable salt thereof, in which Y is -A-R5, in which A is a bond, - (CH2) k-- or - (CD2) k-- and R5 is a C1-C6 straight or branched chain alkyl, C3-C6 cycloalkyl, aryl or --NRa'Rb ', or is a monocyclic or bicyclic ring structure, unsaturated, saturated or partially saturated containing a total of five to eleven atoms having one to three heteroatoms independently selected from the group consisting of oxygen, nitrogen and sulfur, wherein said alkyl, C3-C6 cycloalkyl, aryl or monocyclic ring structure or bicyclic is also optionally substituted with one or more substituents selected from the group consisting of deuterium, halo, C1-C6 straight or branched chain alkyl, CN, hydroxyl, CF3, --ORe, --NReRf, --S ( O) pRe and C3-C6 cycloalkyl, wherein said alkyl and cycloalkyl can be optionally substituted with one or more of its substituents selected from the group consisting of halo, CN, hydroxyl, CONH2 and SO2CH3, in which (a) Ra 'and Rb' are independently hydrogen, deuterium, C1-C6 straight or branched chain alkyl, C3-C6 cycloalkyl, aryl, (C1-C6 straight or branched chain alkyl) aryl, heteroaryl or (C1-C6 straight or branched chain alkyl) heteroaryl, wherein said alkyl and cycloalkyl can be optionally substituted with one or more Rc ', or (b ) Ra 'and Rb' together form a chain comprising - (CRc'Rd ') and--, in which Rc' and Rd 'are independently hydrogen, deuterium, C1-C6 straight or branched chain alkyl, aryl, (C1-C6 straight or branched chain alkyl) aryl, heteroaryl, (C1-C6 straight or branched chain alkyl) heteroaryl, halo, CN, hydroxyl, CF3, CONH2, - 20 ORe, --NReRf or --S (O) pRe; wherein Re and Rf are independently hydrogen, deuterium, C1-C6 straight or branched chain alkyl or C3-C6 cycloalkyl, wherein said alkyl and cycloalkyl can be optionally substituted with one or more substituents selected from the group consisting of halo , CN, hydroxyl, CF3 and CONH2; j is 2, 3, 4 or 5; k is 1, 2; 3 or 4; and p is 0, 1 or 2; in a pharmaceutically acceptable form in combination with one or more additional agents that modulate a mammal's immune system or that are anti-inflammatory. |