http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2712695-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8268e39ce70ff2ad19742e2a21d5a90c |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A40-146 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-335 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8218 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-111 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8261 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N- |
| filingDate | 2004-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3823f24f3a5db9ff120efcc85a790e6a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_135c2c3b9bd8007e038386eff67af44f |
| publicationDate | 2019-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2712695-T3 |
| titleOfInvention | Methods and compositions to control the efficiency of RNA silencing |
| abstract | The use of an RNAi agent to improve RNA silencing of a target mRNA in a non-therapeutic method of RNA silencing performed in a cell that has an RNAi path; wherein the RNAi agent has at least one terminal nucleotide substituted with a nucleotide that forms an oscillating base pair G: U with the corresponding nucleotide in the target mRNA, in which the terminal nucleotide is within 5 or less end nucleotides 3 'of the RNAi agent; wherein the RNAi agent has at least one terminal nucleotide substituted with a nucleotide that forms a pair of oscillating bases G: U with the corresponding nucleotide in the target mRNA, in which the terminal nucleotide is within 5 or less nucleotides of the 5 'end of the RNAi agent; and wherein at least two terminal nucleotides are substituted, in which the two substituted terminal nucleotides are at the 3 'end of the RNAi agent, wherein the method comprises contacting the cell with the RNAi agent under conditions such that silencing be improved. |
| priorityDate | 2003-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 534.