http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2712190-T3
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf32b60391b469c41e86c353437f5751 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-52 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4162 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-401 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06 |
filingDate | 2013-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2019-05-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_03dfbd31eb0483a9c3554d6ce50315f9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f94e5a475d8d6f99b86a1418277e55e2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_812764f72bb07e8f0a9b224c0e90f6b4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7bceb7287f54ad73b96bc538d4b699c1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_50a944871e2f47bd366d3a3e2a64e310 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_496e8887a25a57a7a363e249383dd8a0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8799c79205ca4d7386c1108b9189dc9e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_421b0d7ae31e17e1b49e48e5dfa50af6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e4862fb4d5237c889a094bd8738440c2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d5ba46115a984b90e37ff0bdb2eeb374 |
publicationDate | 2019-05-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | ES-2712190-T3 |
titleOfInvention | Modulators of the complement pathway and its uses |
abstract | The compound, or a salt thereof, selected from the group consisting of: (3,3-dimethyl-cyclobutyl) -amide of the acid (1R, 3S, 5R) -2- [2- (3-Acetyl-pyrazolo [3 , 4-c] pyridin-1-yl) -acetyl] -2-aza-bicyclo [3.1.0] hexane-3-carboxylic; (1R, 3S, 5R) -2- [2- (3-Acetyl-pyrazolo [3,4-b] pyridin-1-yl) -acetyl] -2 (2,2-dimethyl-cyclopropyl) -amide -aza-bicyclo [3.1.0] hexane-3-carboxylic; (1R, 3S, 5R) -2- [2- (3-Acetyl-pyrazolo [3,4-b] pyridin-1-yl) -acetyl] -2 (2,2-difluoro-cyclopropyl) -amide -aza-bicyclo [3.1.0] hexane-3-carboxylic; ((1R, 2S) -2-fluoro-cyclopropyl) -amide of the acid (1R, 3S, 5R) -2- [2- (3-Acetyl-pyrazolo [3,4-b] pyridin-1-yl) - acetyl] -2-aza-bicyclo [3.1.0] hexane-3-carboxylic; (3,3R-Trimethyl-cyclohexyl) -amide of the acid (1R, 3S, 5R) -2- [2- (3-Acetyl-pyrazolo [3,4-b] pyridin-1-yl) -acetyl] -2-aza-bicyclo [3.1.0] hexane-3-carboxylic; (3,3R,5-Tetramethyl-cyclohexyl) -amide of the acid (1R, 3S, 5R) -2- [2- (3-Acetyl-pyrazolo [3,4-b] pyridin-1-yl) - acetyl] -2-aza-bicyclo [3.1.0] hexane-3-carboxylic; (1R, 3S, 5R) -2- [2- (3-Acetyl-pyrazolo [3,4-c] pyridin-1-yl) (2,2-dimethyl-tetrahydro-pyran-4-yl) -amide ) -acetyl] -2- aza-bicyclo [3.1.0] hexane-3-carboxylic; (1R, 3S, 5R) -2- [2- (3-Acetyl-pyrazolo [3,4-c] pyridin-1-yl) -acetyl] -2 (3,3-difluoro-cyclobutyl) -amide -aza-bicyclo [3.1.0] hexane-3-carboxylic; (3,3-Difluoro-cyclohexyl) -amide of the acid (1R, 3S, 5R) -2- [2- (3-Acetyl-pyrazolo [3,4-c] pyridin-1-yl) -acetyl] -2 -aza-bicyclo [3.1.0] hexane-3-carboxylic; (1R, 3S, 5R) -2- [2- (3-Acetyl-pyrazolo [3,4-c] pyridin-1-yl) -acetyl] -2-aza (1-hydroxymethyl-cyclohexyl) -amide - bicyclo [3.1.0] hexane-3-carboxylic; (4R-Difluoro-cyclohexyl) -amide of the acid (1R, 3S, 5R) -2- [2- (3-Acetyl-pyrazolo [3,4-c] pyridin-1-yl) -acetyl] -2 -aza-bicyclo [3.1.0] hexane-3-carboxylic; ((1R, 3R) -3-carbamoyl-cyclopentyl) -amide of the acid (1R, 3S, 5R) -2- [2- (3-Acetyl-pyrazolo [3,4-b] pyridin-1-yl) - acetyl] -2-aza-bicyclo [3.1.0] hexane-3-carboxylic; (1R, 3R) -3 - ({(1R, 3S, 5R) -2- [2- (3-Acetyl-pyrazolo [3,4-b] pyridin-1-yl) -acetyl] acid methyl ester - 2-aza-bicyclo [3.1.0] hexane-3-carbonyl} -amino) -cyclopentanecarboxylic; (1R, 3S) -3 - ({(1R, 3S, 5R) -2- [2- (3-Acetyl-pyrazolo [3,4-b] pyridin-1-yl) -acetyl] acid methyl ester - 2-aza-bicyclo [3.1.0] hexane-3-carbonyl} -amino) -cyclohexanecarboxylic; 2 - [(1-carbamoyl-1H-indole-3-yl) -amide] 3-cyclohexylamide (1R, 3S, 5R) -2-Aza-bicyclo [3.1.0] hexane-2,3-dicarboxylic acid; 2 - [(1-carbamoyl-1H-indole-3-yl) -amide] 3- (S) -cyclohex-2-enylamide (1R, 3S, 5R) -2-Aza-bicyclo [3.1.0] hexane-2,3-dicarboxylic; Acid 2 - [(1-carbamoyl-1H-indole-3-yl) -amide] 3 - {[(1S, 3R) -3- (2,2,2-trifluoro-ethoxy) -cyclohexyl] -amide} (1R, 3S, 5R) -2-Aza-bicyclo [3.1.0] hexane-2,3-dicarboxylic; Acid 2 - [(1-carbamoyl-1H-indole-3-yl) -amide] 3 - {[(1R, 3S) -3- (2,2,2-trifluoro-ethoxy) -cyclohexyl] -amide} (1R, 3S, 5R) -2-Aza-bicyclo [3.1.0] hexane-2,3-dicarboxylic; Acid 2 - [(1-carbamoyl-1H-indole-3-yl) -amide] 3 - {[(1S, 3S) -3- (2,2,2-trifluoro-ethoxy) -cyclohexyl] -amide} (1R, 3S, 5R) -2-Aza-bicyclo [3.1.0] hexane-2,3-dicarboxylic; Acid 2 - [(1-carbamoyl-1H-indole-3-yl) -amide] 3 - {[(1R, 3R) -3- (2,2,2-trifluoro-ethoxy) -cyclohexyl] -amide} (1R, 3S, 5R) -2-Aza-bicyclo [3.1.0] hexane-2,3-dicarboxylic; (1R, 3S, 5R) -2- acid 2 - [(1-carbamoyl-1H-indole-3-yl) -amide] 3 - [((1R, 3S) -3-methoxy-cyclohexyl) -amide] Azabicyclo [3.1.0] hexane-2,3-dicarboxylic; (1R, 3S, 5R) -2- acid 2 - [(1-carbamoyl-1H-indole-3-yl) -amide] 3 - [((R) -3,3-dimethyl-cyclohexyl) -amide] Azabicyclo [3.1.0] hexane-2,3-dicarboxylic; (1R, 3S, 5R) -2- acid 2 - [(1-carbamoyl-1H-indole-3-yl) -amide] 3 - [((1R, 3S) -3-ethyl-cyclohexyl) -amide] Aza-bicyclo [3.1.0] hexane-2,3-dicarboxylic; (1R, 3S, 5R) -2- acid 2 - [(1-carbamoyl-1H-indole-3-yl) -amide] 3 - [((1S, 3R) -3-ethyl-cyclohexyl) -amide] Aza-bicyclo [3.1.0] hexane-2,3-dicarboxylic; (1R, 3S, 5R) -2- acid 2 - [(1-carbamoyl-1H-indole-3-yl) -amide] 3 - [((1R, 3S) -3-methyl-cyclohexyl) -amide] Azabicyclo [3.1.0] hexane-2,3-dicarboxylic; (1R, 3S, 5R) -2- acid 2 - [(1-carbamoyl-1H-indole-3-yl) -amide] 3 - [((1R, 3S) -3-trifluoromethyl-cyclohexyl) -amide] Azabicyclo [3.1.0] hexane-2,3-dicarboxylic; (2S, 4R) -4-Fluoro- acid 1 - [(1-carbamoyl-1H-indole-3-yl) -amide] 2 - [((R) -3,3-dimethyl-cyclohexyl) -amide] pyrrolidine-1,2-dicarboxylic; 1- {2 - [(1R, 3S, 5R) -3- (3,3-Dimethyl-piperidin-1-ylcarbamoyl) -2-aza-bicyclo [3.1.0] hex-2-yl] acid amide - 2-oxo-ethyl} -6-methyl-1H-indazol-3-carboxylic; 1- {2 - [(1R, 3S, 5R) -3- (3,3-Dimethyl-piperidin-1-ylcarbamoyl) -2-aza-bicyclo [3.1.0] hex-2-yl] acid amide - 2-oxo-ethyl} -5-methyl-1H-pyrazolo [3,4-c] pyridine-3-carboxylic; (3,3-Dimethyl-piperidin-1-yl) -amide of the acid (1R, 3S, 5R) -2 - {2- [3-Acetyl-5- (pyrimidin-2-ylmethoxy) -indazol-1-yl ] - acetyl} -2-aza-bicyclo [3.1.0] hexane-3-carboxylic; (1R, 3S, 5R) -2- [2- (3-Acetyl-pyrazolo [3,4-c] pyridin-1-yl) -acetyl] (3-hydroxy-3-trifluoromethyl-cyclohexyl) -amide - 2-aza-bicyclo [3.1.0] hexane-3-carboxylic; (1R, 3S, 5R) -2- [2- (3-Acetyl-indazol-1-yl) -acetyl] -2-azabicyclo (trans-3-trifluoromethoxy-cyclohexyl) -amide ] hexane-3-carboxylic; 1- {2-Oxo-2 - [(1R, 3S, 5R) -3- (trans-3-trifluoromethoxy-cyclohexylcarbamoyl) -2-aza-bicyclo [3.1.0] hex-2-yl] amide - ethyl} -1H-indazol-3-carboxylic; 1- {2 - [(1R, 3S, 5R) -3- (3-Hydroxy-3-trifluoromethyl-cyclohexylcarbamoyl) -2-aza-bicyclo [5 3.1.0] hex-2-yl] -2 acid amide -oxo-ethyl} -1H-pyrazolo [3,4-c] pyridine-3-carboxylic; 1- {2 - [(1R, 3S, 5R) -3- (2,2-Difluoro-cyclohexylcarbamoyl) -2-aza-bicyclo [3.1.0] hex-2-yl] -2-oxo- amide ethyl} -1H-pyrazolo [3,4-c] pyridine-3-carboxylic; ((S) -2,2-Difluoro-cyclohexyl) -amide of the acid (1R, 3S, 5R) -2- {2- [3-Acetyl-5- (pyrimidin-2-ylmethoxy) -indazol-1-yl ] - acetyl} -2-aza-bicyclo [3.1.0] hexane-3-carboxylic; ((R) -2,2-Difluoro-cyclohexyl) -amide of the acid (1R, 3S, 5R) -2- {2- [3-Acetyl-5- (pyrimidin-2-ylmethoxy) -indazol-1-yl ] - acetyl} -2-aza-bicyclo [3.1.0] hexane-3-carboxylic; (2-Fluoro-cyclohex-2-enyl) -amide of the acid (1R, 3S, 5R) -2- {2- [3-acetyl-5- (pyrimidin-2-ylmethoxy) -indazol-1-yl] - acetyl} -2-aza-bicyclo [3.1.0] hexane-3-carboxylic; 1- {2 - [(1R, 3S, 5R) -3- (3-Methoxy-3-trifluoromethyl-cyclohexylcarbamoyl) -2-aza-bicyclo [3.1.0] hex-2-yl] - 2- acid amide oxo-ethyl} -1H-indazol-3-carboxylic; 1- {2 - [(1R, 3S, 5R) -3- (3-Methoxy-3-trifluoromethyl-cyclohexylcarbamoyl) -2-aza-bicyclo [3.1.0] hex-2-yl] - 2- acid amide oxo-ethyl} -1H-indazol-3-carboxylic; 1- {2-Oxo-2 - [(1R, 3S, 5R) -3 - (((1R, 3S) -3-trifluoromethyl-cyclohexylcarbamoyl) -2-aza-bicyclo [3.1.0] hex- 2 amide -yl] -ethyl} -1H-pyrazolo [3,4-c] pyridine-3-carboxylic; ((1S, 3S) -3-methoxy-cyclohexyl) -amide of the acid (1R, 3S, 5R) -2- [2- (3-Acetyl-indazol-1-yl) -acetyl] -2-azabicyclo [3.1.0] hexane-3-carboxylic; ((1R, 3R) -3-methoxy-cyclohexyl) -amide of the acid (1R, 3S, 5R) -2- [2- (3-Acetyl-indazol-1-yl) -acetyl] -2-azabicyclo [3.1.0] hexane-3-carboxylic; ((1S, 3R) -3-methoxy-cyclohexyl) -amide of the acid (1R, 3S, 5R) -2- [2- (3-Acetyl-indazol-1-yl) -acetyl] -2-azabicyclo [3.1.0] hexane-3-carboxylic; ((1R, 3S) -3-methoxy-cyclohexyl) -amide of the acid (1R, 3S, 5R) -2- [2- (3-Acetyl-indazol-1-yl) -acetyl] -2-azabicyclo [3.1.0] hexane-3-carboxylic; 1- {2 - [(1R, 3S, 5R) -3 - ((1R, 3S) -3-Methoxy-cyclohexylcarbamoyl) -2-aza-bicyclo [3.1.0] hex-2-yl] - 2-oxo-ethyl} -1H-indazol-3-carboxylic; 1- {2 - [(1R, 3S, 5R) -3 - ((1R, 3S) -3-Methyl-cyclohexylcarbamoyl) -2-aza-bicyclo [3.1.0] hex-2-yl] - amide 2-oxo-ethyl} -1H-indazol-3-carboxylic; 1- {2 - [(1R, 3S, 5R) -3 - (((1S, 3R) -3-Methyl-cyclohexylcarbamoyl) -2-aza-bicyclo [3.1.0] hex-2-yl] - acid amide 2-oxo-ethyl} -1H-indazol-3-carboxylic; 1- {2-Oxo-2 - [(1R, 3S, 5R) -3 - (((1R, 3S) -3-trifluoromethyl-cyclohexylcarbamoyl) -2-aza-bicyclo [3.1.0] hex- 2 amide -yl] -ethyl} -1H-indazol-3-carboxylic; 5-Methyl-1- {2-oxo-2 - [(1R, 3S, 5R) -3 - ((1R, 3S) -3-trifluoromethyl-cyclohexylcarbamoyl) -2-aza-bicyclo [3.1.0] amide ] hex-2-yl] -ethyl} -1H-pyrazolo [3,4-c] pyridine-3-carboxylic; 1- {2 - [(1R, 3S, 5R) -3 - ((1R, 3S) -3-Methyl-cyclohexylcarbamoyl) -2-aza-bicyclo [3.1.0] hex-2-yl] - amide 2-oxo-ethyl} -1H-pyrazolo [3,4-c] pyridine-3-carboxylic; 1- {2 - [(1R, 3S, 5R) -3- (3,3-Difluoro-cyclopentylcarbamoyl) -2-aza-bicyclo [3.1.0] hex-2-yl] -2-oxo- amide ethyl} -1H-indazol-3-carboxylic; 1- {2 - [(1R, 3S, 5R) -3 - ((S) -3,3-Dimethyl-cyclohexylcarbamoyl) -2-aza-bicyclo [3.1.0] hex-2-yl] - amide 2-oxo-ethyl} -1H-indazol-3-carboxylic; 1- {2 - [(1R, 3S, 5R) -3 - ((R) -3,3-Dimethyl-cyclohexylcarbamoyl) -2-aza-bicyclo [3.1.0] hex-2-yl] acid amide - 2-oxo-ethyl} -1H-indazol-3-carboxylic; 1- {2 - [(1R, 3S, 5R) -3 - ((S) -3,3-Dimethyl-cyclohexylcarbamoyl) -2-aza-bicyclo [3.1.0] hex-2-yl] - amide 2-oxo-ethyl} -1H-pyrazolo [3,4-c] pyridine-3-carboxylic; 1- {2 - [(1R, 3S, 5R) -3 - ((R) -3,3-Dimethyl-cyclohexylcarbamoyl) -2-aza-bicyclo [3.1.0] hex-2-yl] acid amide - 2-oxo-ethyl} -1H-pyrazolo [3,4-c] pyridine-3-carboxylic; 1- {2-Oxo-2 - [(1R, 3S, 5R) -3 - ((S) -spiro [2.5] oct-5-ylcarbamoyl) -2-aza-bicyclo [3.1.0] hex amide -2-yl] -ethyl} -1H-indazol-3-carboxylic; 1- {2-Oxo-2 - [(1R, 3S, 5R) -3 - ((R) -spiro [2.5] oct-5-ylcarbamoyl) -2-aza-bicyclo [3.1.0] hex amide -2-yl] -ethyl} -1H-indazol-3-carboxylic; 1- {2 - [(1R, 3S, 5R) -3 - ((R) -3,3-Dimethyl-cyclohexylcarbamoyl) -2-aza-bicyclo [3.1.0] hex-2-yl] acid amide - 2-oxo-ethyl} -5-methyl-1H-indazol-3-carboxylic; 1- {2 - [(1R, 3S, 5R) -3 - ((R) -3,3-Dimethyl-cyclohexylcarbamoyl) -2-aza-bicyclo [3.1.0] hex-2-yl] acid amide - 2-oxo-ethyl} -6-fluoro-1H-indazol-3-carboxylic; 1- {2 - [(1R, 3S, 5R) -3 - ((R) -3,3-Dimethyl-cyclohexylcarbamoyl) -2-aza-bicyclo [3.1.0] hex-2-yl] acid amide - 2-oxo-ethyl} -6-methyl-1H-indazol-3-carboxylic; 6-Chloro-1- {2 - [(1R, 3S, 5R) -3 - ((R) -3,3-dimethyl-cyclohexylcarbamoyl) -2-aza-bicyclo [3.1.0] hex-2 amide -yl] -2-oxo-ethyl} -1H-indazol-3-carboxylic; 1- {2 - [(1R, 3S, 5R) -3 - ((R) -3,3-Dimethyl-cyclohexylcarbamoyl) -2-aza-bicyclo [3.1.0] hex-2-yl] acid amide - 2-oxo-ethyl} -5-methyl-1H-pyrazolo [3,4-c] pyridine-3-carboxylic; 1- {2 - [(1R, 3S, 5R) -3 - ((R) -3,3-Dimethyl-cyclohexylcarbamoyl) -2-aza-bicyclo [3.1.0] hex-2-yl] acid amide - 2-oxo-ethyl} -5-ethyl-1H-pyrazolo [3,4-c] pyridine-3-carboxylic; |
priorityDate | 2012-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
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