http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2711936-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8de5520d67b0ce661a2b197ee7f24b57 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_431309bc8dab94a0ee0e2aa5aeacd48d |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 |
| filingDate | 2010-09-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aad5788c3148302c016ece3a4f1524c6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_423344499fa48983be6e9fcec33f6b3b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9f3834778b3522d49faff09b3446c809 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2aeeb021223889c15d0ac8a2fd2874e7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_79e468384b5f004300606c91f9532a5d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b7572a2286785fa7144fbeff4039f19d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bc3445f3d139ebdbf91b37e2ab511241 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4a4872a3add0821465598705b5cd0a04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3d7ba420f7f67daf32b3d522fd8157a4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_24f8ebb8b83798a00690cb75155faf20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5167a5525c87a252a974ff7e463e0212 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_04c1899b7c5895697cba7b726b30cdb2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0a7b9126a61392e1e0992b9c53b53142 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e713a79e705150ea3660906d7bc24ae8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4e45e76a3ae52233d3a17e53116f6372 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1b8d725f343b02264f00cb8996ccc6fd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_59779488765d688574d021c6c4d843a8 |
| publicationDate | 2019-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2711936-T3 |
| titleOfInvention | Bruton tyrosine kinase inhibitors |
| abstract | A compound having the formula: ** Formula ** wherein: X1 is -O-, -CR5R6- or -NR7-; X2 is = CR8- or = N-; p is 0-5; y is 0, 1, or 2; z is 0, 1, or 2, where z is 0 or 1 when y is 2, and z is 1 or 2 when y is 0; each R1 is independently halogen, -NO2, -CN, -OR, -SR, -N (R) 2, -C (O) R, -CO2R, -C (O) C (O) R, - C (O ) CH2C (O) R, -S (O) R, -S (O) 2R, -C (O) N (R) 2, -SO2N (R) 2, -OC (O) R, -N (R ) C (O) R, -N (R) N (R) 2, - N (R) C (= NR) N (R) 2, -C (= NR) N (R) 2, -C = NOR , -N (R) C (O) N (R) 2, -N (R) SO2N (R) 2, -N (R) SO2R, -OC (O) N (R) 2, or an optionally substituted group selected from C1-12 aliphatic, phenyl, a 3-7 membered saturated or partially unsaturated monocyclic carboxylic ring, a 7-10 membered saturated or partially unsaturated bicyclic carboxylic ring, a 3-7 membered saturated or partially unsaturated monocyclic heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur, a 7-10 membered saturated or partially unsaturated bicyclic heterocyclic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, a bicyclic aryl ring of 8-10 members, a 5-6 membered heteroaryl ring that has 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or an 8-10 membered bicyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or: two R1 groups in adjacent carbon atoms are taken together with its intervening atoms to form an optionally substituted ring selected from phenyl, a 3-7 membered saturated or partially unsaturated monocyclic carboxylic ring, a 7-10 membered saturated or partially unsaturated bicyclic carboxylic ring, a saturated or partially unsaturated monocyclic heterocyclic ring 3-7 members having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur, a 7-10 member saturated or partially unsaturated bicyclic heterocyclic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, an 8-10 membered bicyclic aryl ring, a het ring 5-6 member eroaryl having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or an 8-10 membered bicyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or: two R1 groups in non-adjacent carbon atoms are taken together with their intervening atoms to form an optionally substituted bridge of a bicyclic bridge group, wherein the bridge is a C1-3 hydrocarbon chain where a methylene unit is optionally replaced with -NR †, -O-, -C (O) -, - OC (O) -, -C (O) O-, -SS-, or -S-, or: two R1 groups on the same atom of carbon are taken together with their intervening atoms to form an optionally substituted fused spiro ring selected from a 3-7 membered saturated or partially unsaturated carboxylic ring, or a 3-7 membered saturated or partially unsaturated monocyclic heterocyclic ring having 1-2 independent heteroatoms mind selected from nitrogen, oxygen, or sulfur; each R is independently hydrogen or an optionally substituted group selected from aliphatic C1-6, phenyl, a 3-7 membered saturated or partially unsaturated carboxylic ring, a 3-7 membered saturated or partially unsaturated monocyclic heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 5-6 membered heteroaryl ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or: two R groups in the same nitrogen are taken together with their intervening atoms to form an optionally substituted 3-7 membered heteroaryl, saturated or partially unsaturated ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; each of R2, R3, R5, R6, and R8 is independently R, halogen, -NO2, -CN, -OR, -SR, -N (R) 2, -C (O) R, -CO2R, -C (O) C (O) R, -C (O) CH2C (O) R, -S (O) R, -S (O) 2R, -C (O) N (R) 2, -SO2N (R) 2, -OC (O) R, -N (R) C (O) R, - N (R) N (R) 2, -N (R) C (= NR) N (R) 2, -C ( = NR) N (R) 2, -C = NOR, -N (R) C (O) N (R) 2, -N (R) SO2N (R) 2, -N (R) SO2R, or - OC (O) N (R) 2; or: R3 and R4 are optionally taken together with their intervening atoms to form an optionally substituted ring selected from a 3-7 membered saturated or partially unsaturated monocyclic heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 7-10 membered saturated or partially unsaturated bicyclic heterocyclic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur; each of R4 and R7 is independently R, -CN, -C (O) R, -CO2R, -C (O) C (O) R, -C (O) CH2C (O) R, - C (O) N (R) 2, -S (O) R, -S (O) 2R, or -S (O) 2N (R) 2; Ring A1 is: ** Formula ** wherein T is a linear or branched, saturated or unsaturated C1-5 hydrocarbon chain, where 20 one, two or three units of T methylene are optionally and are independently replaced with - C (R) 2-, -NR †, -N (R) C (O) -, -C (O) N (R) -, -N (R) SO2-, -SO2N (R) -, -O -, -C (O) -, -OC (O) -, -C (O) O-, -S-, - SO-, -SO2-, -C (= S) -, -C (= NR) -, -N = N-, or -C (= N2) -; Ring A2 is an optionally substituted ring selected from phenyl, a 3-7 membered saturated or partially unsaturated monocyclic carboxylic ring, a 7-10 membered saturated or partially unsaturated bicyclic carboxylic ring, a 3- or 3-unsaturated saturated or partially unsaturated monocyclic heterocyclic ring 7 members having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur, a 7-10 member saturated or partially unsaturated bicyclic heterocyclic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, an aryl ring 8-10 membered bicyclic, a 5-6 membered heteroaryl ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or an 8-10 membered bicyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; L is a linear or branched, saturated or unsaturated hydrocarbon chain optionally substituted C1-7 bivalent or covalent bond, wherein one, two or three methylene units of L are independently replaced with -Cy-, -CR2-, -NR † , -N (R) C (O) -, -C (O) N (R) -, -N (R) SO2-, -SO2N (R) -, -O-, - C (O) -, - OC (O) -, -C (O) O-, -S-, -SO-, -SO2-, -C (= S) -, -C (= NR) -, -N = N-, or - C (= N2) -, where at least one methylene unit of L is replaced with -N (R) -; and each Cy is independently an optionally substituted bivalent ring selected from phenylene, a saturated or partially unsaturated 3-7 membered carbocyclylene, a saturated or partially unsaturated 3-7 membered monocyclic heterocyclylene having 1-2 heteroatoms independently selected from nitrogen, oxygen , or sulfur, or a 5-6 membered heteroarylene having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur; wherein further suitable monovalent substituents on a substitutable carbon atom of an "optionally substituted" group are independently halogen; - (CH2) 0-4R †; - (CH2) 0-4OR †; -O (CH2) 0-4R †, -O- (CH2) 0-4C (O) OR †; - (CH2) 0-4CH (OR †) 2; - (CH2) 0-4SR †; - (CH2) 0-4Ph, which can be substituted with R †; - (CH2) 0-4O (CH2) 0-1Ph which can be substituted with R †; -CH = CHPh, which can be substituted with R †; - (CH2) 0-4O (CH2) 0-1-pyridyl which can be substituted with R †; -NO2; -CN; -N3; - (CH2) 0-4N (R †) 2; - (CH2) 0-4N (R †) C (O) R †; -N (R †) C (S) R †; - (CH2) 0-4N (R †) C (O) NR † 2; -N (R †) C (S) NR † 2; - (CH2) 0-4N (R †) C (O) OR †; -N (R †) N (R †) C (O) R †; - N (R †) N (R †) C (O) NR † 2; -N (R †) N (R †) C (O) OR †; - (CH2) 0-4C (O) R †; -C (S) R °; - (CH2) 0-4C (O) OR †; - (CH2) 0-4C (O) SR †; - (CH2) 0-4C (O) OSiR † 3 ;-( CH2) 0-4OC (O) R †; -OC (O) (CH2) 0-4SR-, SC (S) SR °; - (CH2) 0-4SC (O) R †; - (CH2) 0-4C (O) NR † 2; - C (S) NR † 2; -C (S) SR °; -SC (S) SR °, - (CH2) 0-4OC (O) NR † 2; -C (O) N (OR †) R †; -C (O) C (O) R †; -C (O) CH2C (O) R †; - C (NOR †) R † ;-( CH2) 0-4SSR †; - (CH2) 0-4S (O) 2R †; - (CH2) 0-4S (O) 2OR †; - (CH2) 0-4OS (O) 2R †; -S (O) 2NR † 2; - (CH2) 0- 4S (O) R †; -N (R †) S (O) 2NR † 2; -N (R †) S (O) 2R †; -N (OR †) R †; -C (NH) NR † 2; -P (O) 2R †; -FOR 2; -OP (O) R † 2; - OP (O) (OR †) 2; SiR † 3 ;-( C1-4; linear or branched alkylene) O-N (R †) 2; or - (C1-4 linear or branched alkylene) C (O) ON (R †) 2 where each R † is independently hydrogen, C1-6; aliphatic, -CH2Ph, -O (CH2) 0-1Ph; wherein further suitable substituents on a substitutable nitrogen of an "optionally substituted" group include -R †, -NR † 2, -C (O) R †, -C (O) OR †, -C (O) C ( O) R †, -C (O) CH2C (O) R †, -S (O) 2R †, -S (O) 2NR † 2, -C (S) NR † 2, -C (NH) NR † 2, or -N (R †) S (O) 2R †; wherein each R † is independently hydrogen, aliphatic C1-6, unsubstituted -OPh, or a 5-6 membered unsaturated saturated or partially unsaturated aryl ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur. |
| priorityDate | 2009-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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