| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_76ba102ea9c02b6633d64bf09c5b89a4 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2750-14143
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2750-14132 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-88
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-861
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-864
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y406-01002
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-51 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-00 |
| filingDate |
2011-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2019-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3db4e3efc28e5ddc6149b13233f58bb4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ee13a860e63c07c24455abacf727d7f8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9c29c6731d3cb835a7335bae70fb8a19 |
| publicationDate |
2019-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
ES-2711256-T3 |
| titleOfInvention |
Compositions of rAAV-guanylate cyclase and methods to treat congenital amaurosis of Leber 1 (LCA1) |
| abstract |
A recombinant adeno-associated viral vector (rAAV) comprising at least one first polynucleotide comprising a photoreceptor-specific human rhodopsin kinase promoter operably linked to at least a first nucleic acid segment encoding at least a first guanylate polypeptide Biologically active human retinal cyclase, comprising at least a first region of contiguous amino acid sequence that is at least approximately 95% identical to a sequence of at least 120 contiguous amino acids of SEQ ID NO: 1, in which The rAAV vector is a recombinant adeno-associated virus (rAAV5) serotype 5 vector or in which the rAAV vector is a recombinant adeno-associated virus serotype 8 (rAAV8) vector. |
| priorityDate |
2010-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |