| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b8ae50a1ac4cd76423a4efc15db872d1 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-21 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-31
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J20-286
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-1271
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01D15-3809
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01D15-3804
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J20-3274
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J20-3272 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01D15-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-31
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-22 |
| filingDate |
2012-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2019-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9acf44c7a9e33dbbc427a7b2773d4bec
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3e531d3e4718bcd3b1e46dad22ab578d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_184c71cd8ce53dba72b40dd98a5ce230
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2021dd070fbfa279731f18eeb3b57481 |
| publicationDate |
2019-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
ES-2710204-T3 |
| titleOfInvention |
Chromatography matrices that include new ligands based on protein A of Staphylococcus aureus |
| abstract |
An affinity chromatography matrix comprising a solid support with an affinity chromatography ligand that comprises either one or more B domains of Staphylococcus aureus Protein A (SpA) with the amino acid sequence shown in SEQ ID NO .: 3 or encoded by the nucleotide sequence shown in SEQ ID NO .: 9, or one or more Z domains of SpA with the amino acid sequence shown in SEQ ID NO .: 6 or encoded by the nucleotide sequence shown in SEQ ID NO .: 12, where at least one of the one or more domains is mutated to delete three, four or five consecutive amino acids from the N-terminus, starting at position 1 or position 2 of SEQ ID NO: 3 or SEQ ID NO.:6; wherein the ligand exhibits reduced fragmentation with respect to a wild-type equivalent, after exposure to 0.5M NaOH for at least 5 hours. |
| priorityDate |
2011-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |