| abstract |
Isolated antibody, or antigen-binding fragment thereof, which binds CD40 and is a CD40 agonist, comprising (i) a heavy chain variable region comprising the VHCDR1 region set forth in SEQ ID NO: 3, the region VHCDR2 set forth in SEQ ID NO: 4 and the VHCDR3 region set forth in SEQ ID NO: 5; (ii) a light chain variable region comprising the VLCDR1 region set forth in SEQ ID NO: 6, the VLCDR2 region set forth in SEQ ID NO: 7 and the VLCDR3 region set forth in SEQ ID NO: 8. |