| abstract |
A compound of formula (I): ** Formula ** or a pharmaceutically acceptable salt thereof; where: ----- represents a single or double bond; R1 is C1-6 alkyl optionally substituted with alkoxy or one or two halo groups (eg, fluorine); R is hydrogen, halogen, substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted C 2-6 alkenyl, substituted or unsubstituted C 2-6 alkynyl, substituted or unsubstituted C 3-6 carbocyclyl or -OR 2, wherein RA 2 is hydrogen or substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted C 2-6 alkenyl, substituted or unsubstituted C 2-6 alkynyl or substituted or unsubstituted C 3-6 carbocyclyl; R 3a is hydrogen u -ORA 3, wherein RA 3 is hydrogen or substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted C 2-6 alkenyl, substituted or unsubstituted C 2-6 alkynyl or substituted or unsubstituted C 3-6 carbocyclyl and R 3b it is hydrogen; or R3a and R3b join to form an oxo group (= O); each time R4a and R4b are independently hydrogen, substituted or unsubstituted C1-6 alkyl or halogen, provided that the ----- between C5 and C6 is a single bond, then each of the hydrogens in C5 and R4a is provides independently in the alpha or beta configuration and R4b is absent; each time R5, R6 and R7 are independently hydrogen, halogen, -NO2, -CN, -ORGA, -N (RGA) 2, -C (= O) RGA, -C (= O) ORGA, - OC (= O) RGA, -OC (= O) ORGA, -C (= O) N (RGA) 2, -N (RGA) C (= O) RGA, -OC (= O) N (RGA) 2 , - N (RGA) C (= O) ORGA, -N (RGA) C (= O) N (RGA) 2, -SRGA, -S (= O) RGA, -S (= O) 2RGA, -S (= O) 2ORGA, -OS (= O) 2RGA, - S (= O) 2N (RGA) 2, -N (RGA) S (= O) 2RGA, substituted or unsubstituted C 1-6 alkyl, C 2- alkenyl 6 substituted or unsubstituted, substituted or unsubstituted C 2-6 alkynyl, substituted or unsubstituted C 3-6 carbocyclyl or substituted or unsubstituted 3 to 6-membered heterocyclyl; and at least one of R5, R6, and R7 is halogen (e.g., -F, -Cl, -Br), -NO2, -CN, -ORGA, -N (RGA) 2, -C (= O) RGA , - C (= O) ORGA, -SRGA, -S (O) RGA, -S (= O) 2RGA, -S (= O) 2ORGA, -OS (= O) 2RGA, -S (= O) 2N (RGA) 2, substituted or unsubstituted C 1-6 alkyl (for example, -CH 3, -CH 2 CH 3, haloalkyl, for example, -CF 3), wherein RGA is substituted or unsubstituted C 1-2 alkyl; and each time RGA occurs is independently hydrogen, substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted C 2-6 alkenyl, substituted or unsubstituted C 2-6 alkynyl, substituted or unsubstituted C 3-6 carbocyclyl, heterocyclyl 3 6 members substituted or unsubstituted, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, an oxygen protecting group when attached to oxygen, nitrogen protecting group when attached to nitrogen, or two RGA groups are taken together with the atoms intervening to form a substituted or unsubstituted heteroaryl or heterocyclyl ring. |