http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2709108-T3
Outgoing Links
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| filingDate | 2010-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_80e5bb13b306b9f446d538a2a28e3b17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f91ac6d5ff163fb9567a8d7e2c6ec0bf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a103b1ce6a96a1d79091a7fc6fb15938 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_da1eeaad1598bbaa0848007b3be43d49 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4ce20ed776aa0f49763ec46474e0e7c4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aab1a8ae41bb4eebb3b372cf644626ce |
| publicationDate | 2019-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2709108-T3 |
| titleOfInvention | Heterocyclic compounds and uses thereof |
| abstract | A compound of the formula: ** Formula ** or a pharmaceutically acceptable salt thereof, where W1 is S, N, NR3 or CR3, W2 is N or CR4, W3 is S, N or CR5, W4 is N or C, where no more than two N atoms and no more than two C = O groups are adjacent; W5 is N or CR7; W6 is N or CR8; R1 is hydrogen, alkyl, heteroalkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, alkoxy, heterocycloalkyloxy, amido, acyl, acyloxy, alkoxycarbonyl, sulfonamido, halo, cyano, hydroxy, nitro, phosphate carbonate, or NR'R "where R 'and R" are taken together with nitrogen to form a cyclic moiety; R2 is unsubstituted amino; R3 and R4 are independently hydrogen, alkyl, heteroalkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, alkoxy, heterocycloalkyloxy, amido, amino, acyl, acyloxy, alkoxycarbonyl, sulfonamido, halo, cyano, nitro, cyano , phosphate, urea or carbonate; or R3 and R4 taken together form a cyclic moiety; and R5, R7 and R8 are independently hydrogen, alkyl, heteroalkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, alkoxy, heterocycloalkyloxy, amido, amino, acyl, acyloxy, alkoxycarbonyl, sulfonamido, halo hydroxy, nitro, phosphate, urea, carbonate, or NR'R "where R 'and R" are taken together with nitrogen to form a cyclic moiety; where: "alkyl" refers to a linear or branched hydrocarbon chain radical consisting solely of carbon and hydrogen atoms, which does not contain unsaturation, having one to ten carbon atoms; "heteroalkyl" refers to an alkyl radical having one or more skeletal chain atoms selected from an atom other than carbon; "alkenyl" refers to a linear or branched hydrocarbon chain radical consisting solely of carbon and hydrogen atoms, containing at least one double bond and having two to ten carbon atoms; "alkynyl" refers to a linear or branched hydrocarbon chain radical consisting solely of carbon and hydrogen atoms, which contains at least one triple bond, having two to ten carbon atoms; "cycloalkyl" refers to a monocyclic or polycyclic radical containing only carbon and hydrogen, and may be saturated, or partially unsaturated, where the cycloalkyl groups include groups having 3 to 10 ring atoms; "heterocycloalkyl" refers to a stable 3 to 18 membered non-aromatic ring radical comprising two to twelve carbon atoms and one to six heteroatoms selected from nitrogen, oxygen and sulfur; "aryl" refers to an aromatic radical with six to ten atoms in the ring that has at least one ring that has a conjugated pi electron system that is carbocyclic; "arylalkyl" refers to an (aryl) alkyl radical where the arylalkyl moiety is attached through the alkyl part of the moiety; "heteroaryl" refers to a 5-18 membered aromatic radical that includes one or more ring heteroatoms selected from nitrogen, oxygen and sulfur, and which may be a monocyclic, bicyclic, tricyclic or tetracyclic ring system; "heteroarylalkyl" refers to a moiety that has a heteroaryl moiety connected to an alkyl moiety, where the connection to the rest of the molecule is through the alkyl group; "alkoxy" refers to the group -O-alkyl, which includes 1 to 8 carbon atoms of linear, branched and cyclic configuration and combinations thereof attached to the precursor structure through an oxygen; "heterocycloalkyloxy" refers to a (heterocycloalkyl) -O- moiety, where the heterocycloalkyl moiety is attached through a carbon atom to oxygen, where oxygen functions as a linker to bind the moiety to an "amido" compound refers to to a chemical moiety with formula -C (O) N (R) 2 or -NHC (O) R, where R is selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, heteroaryl attached through a ring of carbon and heteroalicyclic bonded through a carbon ring, each of these moieties may itself be optionally substituted, or where R3 is amido of formula -C (O) N (R) 2, said groups (R) 2 taken together with the nitrogen to which they are attached form an optionally substituted 4, 5, 6 or 7 member ring; "amino" refers to a radical group -N (Ra) 2, where each Ra is independently hydrogen, alkyl, fluoroalkyl, carbocyclyl, carbocyclylalkyl, aryl, aralkyl, heterocycloalkyl, heterocycloalkylalkyl, heteroaryl or heteroarylalkyl; "acyl" refers to the (alkyl) -C (O) -, (aryl) -C (O) -, (heteroaryl) -C (O) -, (heteroalkyl) -C (O) - and (heterocycloalkyl) groups ) -C (O) -, where the group is attached to the precursor structure through carbonyl functionality; "acyloxy" refers to a radical R (C = O) O- where "R" is alkyl, aryl, heteroaryl, heteroalkyl or heterocycloalkyl; "alkoxycarbonyl" refers to a group of the formula (alkoxy) (C = O) - linked through carbonyl carbon where the alkoxy group has the indicated number of carbon atoms; "sulfonamido" refers to a radical -S (= O) 2-NRR, where each R is independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, heteroaryl attached through a carbon ring and heteroalicyclic attached through a carbon ring where the R -NRR groups of the radical -S (= O) 2-NRR can be taken together with the nitrogen to which they are attached to form a 4, 5, 6 or 7-membered ring ; "halo" refers to fluorine, chlorine, bromine or iodine; wherein each of the groups alkyl, heteroalkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, alkoxy, heterocycloalkyloxy, amido, amino, acyl, acyloxy, alkoxycarbonyl and sulfonamido is optionally substituted with one or more substituents they are independently: alkyl, heteroalkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, hydroxy, halo, cyano, trifluoromethyl, trifluoromethoxy, nitro, trimethylsilanyl, -ORa, -SRa -Oa (OC) , -N (Ra) 2, -C (O) Ra, -C (O) ORa, -OC (O) N (Ra) 2, -C (O) N (Ra) 2, -N (Ra) C (O) ORa, -N (Ra) C (O) Ra, -N (Ra) C (O) N (Ra) 2, N (Ra) C (NRa) N (Ra) 2, -N (Ra) S (O) tRa (where t is 1 or 2), -S (O) tORa (where t is 1 or 2), -S (O) tN (Ra) 2 (where t is 1 or 2), or PO3 (Ra) 2 where each Ra is independently hydrogen, alkyl, fluoroalkyl, carbocyclyl, carbocyclylalkyl, aryl, aralkyl, heterocycloalkyl, heterocycloalkylalkyl, heteroaryl or heteroarylalkyl ilo. |
| priorityDate | 2009-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 1546.