| abstract |
A compound having the formula: ** Formula ** or a pharmaceutically acceptable salt or solvate thereof, wherein: R2 is selected from the group consisting of H and C1-C8 alkyl; R3 is selected from the group consisting of H, C1-C8 alkyl, C3-C8 carbocycle, aryl, C1-C8 alkyl-aryl, X1- (C3-C8 carbocycle), C3-C8 heterocycle and X1- (C3- heterocycle C8); R4 is selected from the group consisting of H, C1-C8 alkyl alkyl, C3-C8 carbocycle, aryl, X1-aryl, C1-C8 alkyl- (C3-C8 carbocycle), C3-C8 heterocycle and X1- (C3 heterocycle -C8); R5 is selected from the group consisting of H and methyl; or R4 and R5 together form a carbocyclic ring and have the formula - (CRaRb) n- in which Ra and Rb are independently selected from the group consisting of H, C1-C8 alkyl and C3-C8 carbocycle and n is selected from the group consisting of 2, 3, 4, 5 and 6; R6 is selected from the group consisting of H and C1-C8 alkyl; R7 is selected from the group consisting of H, C1-C8 alkyl, C3-C8 carbocycle, aryl, X1-aryl, X1- (C3-C8 carbocycle), C3-C8 heterocycle and X1- (C3-C8 heterocycle); each R8 is independently selected from the group consisting of H, OH, C1-C8 alkyl, C3-C8 carbocycle and O- (C1-C8 alkyl); each X1 is independently C1-C10 alkylene; the remainder -NR9Z1 is a phenylalanine bioisoster with a modified amino acid side chain where the phenylalanine bioisoster moiety ** Formula ** has the structure: ** Formula ** |