| abstract |
A device for supplying a gastro-responsive agent for oral intake, the device being configured to be deployed from a folded configuration for oral intake to a deployed configuration for gastric retention, the device comprising: two outer layers (422, 423) between which a functional layer (426) is arranged; the functional layer (426) comprising at least one layer comprising an agent or agent release formulation; the functional layer (426) being configured to impart mechanical resistance to the device sufficient to allow, after unfolding the device, the preservation of said deployed configuration to provide gastric retention, in which the perforations (1110) are formed in said external layers before that the device bends to the folded configuration, characterized in that only said outer layers (422, 423) comprise said perforations (1110). |