| abstract |
Method of inhibiting at least one of the undesired proliferation, survival or growth of a mammalian cell, comprising contacting said cell with an effective amount of a hedgehog iRNA antagonist against a target sequence of the pathway of hedgehog, a target sequence that is a Shh gene, wherein contacting said cell with said hedgehog iRNA antagonist decreases at least one of cell proliferation, survival, or growth, and wherein said hedgehog iRNA antagonist it comprises a nucleic acid sequence that is at least 90% identical to a nucleic acid sequence set forth in any of SEQ ID NO: 5 to 6 and 9 to 12, wherein said method is not a method of treatment of the human or animal body through surgery or therapy. |