| abstract |
An antibody comprising a heavy chain and a light chain, wherein the heavy chain comprises the variable region and the constant region of SEQ ID NO: 2 having one, but not more than one deletion, addition or substitution of amino acids; wherein the light chain comprises the variable region and the constant region of SEQ ID NO: 4; and wherein the antibody binds to an osteoprotegerin ligand (OPGL) and inhibits OPGL binding to an osteoclast differentiation and activation receptor (ODAR), in which an excess of antibody reduces binding by at least 20% as measured in an in vitro competitive binding assay. |