| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a7063bce652339d811d25137eb4641df |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-13034
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-16622 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-522
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y207-01021
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-713
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1211 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-713
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N63-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-522 |
| filingDate |
2014-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2019-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1e884f5567cc68f3707ec2add0ab8c56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bdfe218ed61f05190c68af72a362c36f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c3dc070a0aaa46b2d286bcf6ec9e038c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2cbad17e62b7b180500ac932a02a042f |
| publicationDate |
2019-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
ES-2703341-T3 |
| titleOfInvention |
Diagnostic assay of thymidine kinase for gene therapy applications |
| abstract |
A retroviral particle comprising an HSV-TK polynucleotide comprising a nuclear export sequence (NES), and an HSV-TK substrate bound to a radioactive indicator; for use in a procedure to identify a patient with lesions capable of benefiting from treatment with gene therapy, said procedure comprising: a) administering to the patient the retroviral particle comprising an HSV-TK polynucleotide comprising a nuclear export sequence (NES ); b) administer the HSV-TK substrate attached to a radioactive indicator to the patient; c) measure the relative amount and location of the radioactive signal present in the patient; and d) determine the location of the lesions in the patient, where patients who have (i) a radioactive signal location correlate with the lesions measured in stage (d), and (ii) radioactive signals above a certain threshold ; They identify themselves as capable of benefiting from gene therapy treatment. |
| priorityDate |
2013-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |