http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2702524-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_36c9c4bd9ad7bcda050248f99e8ddc70 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-56 |
| filingDate | 2010-07-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_408ec448195df06835b42cb81c61af15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_58403c25e06affa5defc6a33e2821386 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_109ef565bb91b2331585ab0da91143e4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2801283f35bb4e7f9a76b0ac6e1f91e4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ba940f52bc8983424db699901fea301c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_051370602bb8f74fab1d7de5726bcf20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cd0f1cd839f6b19dead8945202937aaa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0dd3d2ee1895a5ff73906ca63b3baa4b |
| publicationDate | 2019-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2702524-T3 |
| titleOfInvention | Compounds such as hypoxia mimetics, and compositions, and uses of these |
| abstract | A compound of Formula I: ** Formula ** or a pharmaceutically acceptable salt thereof, solvate or chelate thereof, wherein: n is from 1 to 6; R1 is OH, SH, NR3R4, NHC (O) R2, NHSO2R2 or sulfonyl; R2 is H, C1-C6 alkyl or substituted C1-C6 alkyl; R3 and R4 are each independently H, C1-C6 alkyl, substituted C1-C6 alkyl, C1-C6 haloalkyl, substituted C1-C6 haloalkyl; or at least one pair of R3 and R4, together with the same carbon atom to which they are attached, can be attached to form a 3-6 membered ring or a 3-6 membered substituted ring; R5 is OH, SH, NH2, C1-C6 alkyl, substituted C1-C6 alkyl, C1-C6 alkoxy, substituted C1-C6 alkoxy or sulfanyl; R6 and R7 are each independently H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, NR3R4, C (O) OH, OR12, SR12, SO2R12, CN, NO2, halo, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heteroarylalkyl, substituted heteroarylalkyl, heterocycloalkyl, substituted heterocycloalkyl, alkylsilyl, substituted alkylsilyl, alkynylsilyl, substituted alkynylsilyl, alkoxy, substituted alkoxycarbonyl, substituted alkoxycarbonyl, or X-R11; or R6 and R7, together with the carbon atoms to which they are attached, join to form a 4-7 membered ring or a 4-7 membered substituted ring; X is -N (R10) -Y- or -YN (R10) -; Y is C (O), SO2, alkylene, substituted alkylene, alkenylene, substituted alkenylene, alkynylene or substituted alkynylene; R8 is H, heteroaryl, substituted heteroaryl, phenyl or phenyl substituted with halogen, alkyl, alkoxy, haloalkyl or haloalkoxy, wherein at least one of R8 and R9 is phenyl substituted with halogen, alkyl, haloalkyl, alkoxy and haloalkoxy in the position para - or meta- or wherein one of R8 and R9 is phenyl substituted with halogen, alkyl, haloalkyl, alkoxy and haloalkoxy in the para or meta position; and the other of R8 and R9 is H, halogen, OH, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy; or wherein one of R8 and R9 is phenyl substituted with halogen, alkyl, haloalkyl, alkoxy and haloalkoxy in the para or meta position; and the other of R8 and R9 is H; R10 is H, C1-C6 alkyl or substituted C1-C6 alkyl; R11 is H, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, heteroaryl or substituted heteroaryl; and R12 is H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, or NR3R4; "substituted" refers to a group in which one or more hydrogen atoms are each independently replaced by the same or different substituent (s) in which the substituents include -X, -R33, -OH, = O, - OR33, SR33, -SH, = S, -NR33R34, = NR33, -CX3, -CF3, -CN, -NO2, -S (O) 2R33, -OS (O2) OH, -OS (O) 2R33, - OP (O) (OR33) (OR34), -C (O) R33, -C (S) R33, -C (O) OR33, -C (O) NR33R34, -C (O) OH, -C (S ) OR33, -NR35C (O) NR33R34, - NR35C (S) NR33R34, -NR35C (NR33) NR33R34, -C (NR33) NR33R34, -S (O) 2NR33R34, -NR35S (O) 2R33, -NR35C (O) R33, and S (O) R33 where each X is independently a halo; each R33 and R34 are independently hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, heterocycloalkyl substituted, heteroaryl, substituted heteroaryl, heteroarylalkyl, substituted heteroarylalkyl, NR3536, R35 or -S (O) 2R35 or optionally R33 and R34 together with the atom to which R33 and R34 are attached form one or more heterocycloalkyl, substituted heterocycloalkyl, heteroaryl or substituted heteroaryl rings; and R35 and R36 are, independently, hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, heterocycloalkyl substituted, heteroaryl, heteroaryl substituted, heteroarylalkyl, or heteroarylalkyl or substituted R, and together with the nitrogen atom to which R35 and R36 are attached they form one or more heterocycloalkyl, substituted heterocycloalkyl, heteroaryl or substituted heteroaryl rings. |
| priorityDate | 2009-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 414.