http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2701652-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_930dbfaf9af0027ba4121c0a7c4288de |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2760-16134 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2770-20034 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-64 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-145 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-117 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-67 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-67 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63 |
| filingDate | 2013-02-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_af6b0e03d7d025437f2dbfe8ea388deb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f0e3acbc8b2f4de2e4338622a99dcfa9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f7ae0a32c3aa24e6b1de290d3504b60d |
| publicationDate | 2019-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2701652-T3 |
| titleOfInvention | Nucleic acid comprising or coding for a histone stem-loop and a poly (A) sequence or a polyadenylation signal to increase the expression of a coded pathogenic antigen |
| abstract | Nucleic acid sequence comprising or encoding in the 5 '→ 3' direction for: i) - a coding region, which codes for at least one peptide or protein; - at least one histone stem-loop, and - a poly (A), or ii) sequence - a coding region, which codes for at least one peptide or protein; - a poly (A) sequence, and - at least one histone stem-loop, where the at least histone stem-loop in i) or ii) is selected from the following formulas (I) or (II): formula (I) (stem-loop sequence without stem border elements): ** (See formula) ** formula (II) (stem-loop sequence with stem border elements): ** (See formula) ** where elements border of stem 1 or stem 2 N1-6 are a consecutive sequence of 1 to 6, preferably 2 to 6, more preferably 2 to 5, even more preferably 3 to 5, most preferably 4 to 5 or 5N, where each N is independently selected from a nucleotide selected from A, U, T, G and C, or an analogous nucleotide thereof; Stem 1 [N0-2GN3-5] is inverse complementary or partially inverse complementary to stem element 2 and is a consecutive sequence of between 5 to 7 nucleotides; where N0-2 is a consecutive sequence of 0 to 2, preferably 0 to 1, more preferably 1N, where each N is independently selected from a nucleotide selected from A, U, T, G and C, or an analog nucleotide of the same; where N3-5 is a consecutive sequence of 3 to 5, preferably 4 to 5, more preferably 4 N, where each N is independently selected from a nucleotide selected from A, U, T, G and C, or an analogous nucleotide thereof; and where G is guanosine or an analogue thereof and can optionally be replaced by a cytidine or an analogue thereof, with the proviso that its complementary cytidine nucleotide in stem 2 is replaced by guanosine; Loop sequence [N0-4 (U / T) N0-4] is located between the elements stem 1 and stem 2 and is a consecutive sequence of 3 to 5 nucleotides, more preferably 4 nucleotides, where each N0-4 is independently a consecutive sequence of 0 to 4, preferably 1 to 3, more preferably 1 to 2 N, where each N is independently selected from a nucleotide selected from A, U, T, G and C, or or an analogous nucleotide of the themselves; and where U / T represents uridine or optionally thymidine; Stem 2 [N3-5CN0-2] is inverse complementary or partially inverse complementary to the element stem 1, and is a consecutive sequence of 5 to 7 nucleotides; where N3-5 is a consecutive sequence of 3 to 5, preferably 4 to 5, more preferably 4 N, where each N is independently selected from a nucleotide selected from A, U, T, G and C, or an analogous nucleotide thereof; where N0-2 is a consecutive sequence from 0 to 2, preferably 0 to 1, more preferably 1 N, where each N is independently selected from a nucleotide selected from A, U, T, G and C, or an analogous nucleotide thereof; and where C is cytidine or an analogue thereof and can optionally be replaced by a guanosine or an analogue thereof, with the proviso that its complementary guanosine nucleotide in stem 1 is replaced by cytidine; ... |
| priorityDate | 2012-02-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 566.