http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2701069-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ac9f22bc3bc8655b7477baf87e628a5c |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-498 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-538 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-472 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4725 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1007 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-472 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4725 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 |
| filingDate | 2013-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f509bb51ed90b241f4e8d490c7869448 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c4356954dccd903422dc740cf57df853 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_566077d6a9f6a8587789242474c681f3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e181491b0b59f23b9cebdf96eefb77dd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2e388b280ee03275160f6d037630a087 |
| publicationDate | 2019-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2701069-T3 |
| titleOfInvention | PRMT5 inhibitors and their uses |
| abstract | A compound of formula (I): ** Formula ** or a pharmaceutically acceptable salt thereof, wherein it represents a single or double bond; R1 is hydrogen, Rz, or -C (O) Rz, where Rz is optionally substituted C1-6 alkyl; L is -N (R) C (O) -, -C (O) N (R) -, - N (R) C (O) O-, or -OC (O) N (R) -; each R is independently hydrogen or optionally substituted C 1-6 aliphatic; Ar is a monocyclic or bicyclic aromatic ring having 0-4 heteroatoms that are independently selected from nitrogen, oxygen, and sulfur, where Ar is substituted with 0, 1, 2, 3, 4, or 5 Ry groups, as the valence allows ; each Ry is independently selected from the group consisting of halo, -CN, -NO2, optionally substituted aliphatic, optionally substituted carbocyclyl, optionally substituted aryl, optionally substituted heterocyclyl, optionally substituted heteroaryl, -ORA, -N (RB) 2, -SRA , -C (= O) RA, -C (O) ORA, -C (O) SRA, -C (O) N (RB) 2, - C (O) N (RB) N (RB) 2, - OC (O) RA, -OC (O) N (RB) 2, -NRBC (O) RA, -NRBC (O) N (RB) 2, -NRBC (O) N (RB) N (RB) 2, -NRBC (O) ORA, - SC (O) RA, -C (= NRB) RA, -C (= NNRB) RA, -C (= NORA) RA, -C (= NRB) N (RB) 2, -NRBC (= NRB) RB, -C (= S) RA, -C (= S) N (RB) 2, - NRBC (= S) RA, -S (O) RA, -OS (O) 2RA, -SO2RA, -NRBSO2RA, or -SO2N (RB) 2; each RA is independently selected from the group consisting of hydrogen, optionally substituted aliphatic, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, and optionally substituted heteroaryl; each RB is independently selected from the group consisting of hydrogen, optionally substituted aliphatic, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, and optionally substituted heteroaryl, or two RB groups are taken together with their intervening atoms to form a heterocyclic ring optionally replaced; R5, R6, R7, and R8 are independently optionally substituted hydrogen, halo, or aliphatic; each Rx is independently selected from the group consisting of halo, -CN, optionally substituted aliphatic, -OR ', and -N (R ") 2; R 'is optionally substituted hydrogen or aliphatic; each R "is independently hydrogen or optionally substituted aliphatic, or two R '' are taken together with their intervening atoms to form a heterocyclic ring; and n is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10, as the valence allows; where, and unless otherwise indicated, heterocyclyl or heterocyclic refers to a radical of a 3-10 membered non-aromatic ring system having carbon ring atoms and 1-4 ring heteroatoms, wherein each heteroatom is independently selects nitrogen, oxygen, and sulfur; carbocyclyl or carbocyclic refers to a radical of a non-aromatic cyclic hydrocarbon group having from 3 to 10 carbon ring atoms and zero heteroatoms in the non-aromatic ring system; "aryl" refers to a radical of a monocyclic or polycyclic aromatic ring system having 6-14 carbon ring atoms and zero heteroatoms included in the aromatic ring system; and heteroaryl refers to a 5-10 membered monocyclic or bicyclic 4n + 2 aromatic ring system having carbon ring atoms and 1-4 ring heteroatoms included in the aromatic ring system, |
| priorityDate | 2012-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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