http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2700597-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7e6b011f44f29eda80156e4ab3438644 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-12 |
| filingDate | 2015-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_536946ca19c07134403d2a5209c4520b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_276b5bd4f69abe70cbf0c7b7114d65ba http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1d4619810fff0d9e0e20a8df3c0036b0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_872b9f7fe25394c08a50796c238c04ec |
| publicationDate | 2019-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2700597-T3 |
| titleOfInvention | Process for the preparation of (3RS) -3 - [(2SR) - (2-cyclopentyl-2-hydroxy-2-phenylacetyl) oxy] -1,1-dimethylpyrrolidinium |
| abstract | Procedure for preparing glycopyrronium bromide, or another pharmaceutically acceptable salt of glycopyrronium, where the procedure comprises at least the following steps: a) contacting 1-methylpyrrolidin-3-yl-2-cyclopentyl-2-hydroxy-2-phenylacetate with 5-nitroisophthalic acid in an organic solvent / water mixture to provide a 1- methylpyrrolidin-3-yl-2-cyclopentyl-2-hydroxy-2-phenylacetate-5-nitroisophthalic acid salt (compound III) ; Compound III where the ratio of organic solvent to water is a maximum of 10: 1 (V / V) and the amount of 5-nitroisophthalic acid is at least 0.5 mol per 1 mol of 1-methylpyrrolidin-3-yl- 2-cyclopentyl-2-hydroxy -2-phenylacetate, b) isolate the acid salt (RS / SR) 1-methylpyrrolidin-3-yl-2-cyclopentyl-2-hydroxy-2-phenylacetate 5-nitroisophthalic obtained in the step a) by filtration, c) optionally, purifying the acid salt (RS / SR) 1-methylpyrrolidin-3-yl-2-cyclopentyl-2-hydroxy-2-phenylacetate 5-nitroisophthalic acid of step b) by means of techniques of conventional purification, d) treating the (RS / SR) 1-methylpyrrolidin-3-yl-2-cyclopentyl-2-hydroxy-2-phenylacetate 5-nitroisophthalic acid salt of step b) or c) with a base to produce (RS / SR) methyl 1-methylpyrrolidin-3-yl-2-cyclopentyl-2-hydroxy-2-phenylacetate (compound II), e) contacting (RS / SR) 1-methylpyrrolidin-3-yl- 2-cyclopentyl-2-hydroxy-2-phenylacetate from step d) with me bromide linden to give glycopyrronium bromide (compound I), f) optionally, purifying the glycopyrronium bromide from step d) by means of conventional purification techniques, g) optionally, converting the glycopyrronium bromide obtained in step d) or e) in another pharmaceutically acceptable salt or co-crystal. |
| priorityDate | 2014-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 74.