| abstract |
A multifunctional antibody comprising: (a) an antibody that binds to MET and comprises: i) a heavy chain comprising the HCDR1, HCDR2, and HCDR3 heavy chain CDRs consisting of the amino acid sequences of GYTFTDYYMH (SEQ ID NO : 11), RVNPNRRGTTYNQKFEG (SEQ ID NO: 12), and ARANWLDY (SEQ ID NO: 13), respectively; and ii) a light chain comprising the light chain CDRs LCDR1, LCDR2, and LCDR3 consisting of the amino acid sequences of SVSSSVSSIYLH (SEQ ID NO: 14), YSTSNLAS (SEQ ID NO: 15) and QVYSGYPLT (SEQ ID NO : 16), respectively; and (b) a scFv polypeptide that binds to EGFR and comprises: i) an HCVR domain comprising the scFv CDRs scFv-HCDR1, scFv-HCDR2, and scFv-HCDR3 consisting of the GFSLTNYGVH amino acid sequences (SEQ ID NO : 1), VIYSGGNTDYNTPFKG (SEQ ID NO: 2) or VIWSGGNTDYNTPFTG (SEQ ID NO: 7), and ARALDYYDYDFAY (SEQ ID NO: 3), respectively; and ii) an LCVR domain comprising the scFv scRv-LCDR1, scFv-LCDR2, and scFv-LCDR3 CDRs consisting of the RASYSIGTNIH (SEQ ID NO: 4), RYAKESIS (SEQ ID NO: 5) or YYASRSIS amino acid sequences (SEQ ID NO: 8), and QQNNAWPTT (SEQ ID NO: 6), respectively. |