http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2698617-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7134c9fb0602d6a09d1bf63203ce43a6 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C229-64 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-64 |
| filingDate | 2014-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_437fa5f667f3c1e5446003a70500ebea http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ddc4d3266e545fcb3fceb8e010c76a13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e4beb154f96354eeb78ec662eee449bc |
| publicationDate | 2019-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2698617-T3 |
| titleOfInvention | Procedure for the production of high density mesalamine |
| abstract | A process for the production of mesalamine with an apparent density greater than or equal to 0.30 g/ml, essentially free of solvents, comprising the steps consisting of: a) dissolving mesalamine in an aqueous solution of HCl, obtaining an acid solution of mesalamine hydrochloride having a pH <= 2, b) adding the acid solution containing mesalamine HCl to an aqueous solution buffered with a buffer system based on acetic acid and sodium acetate with a pH of 3.5 to 4, 5 to increase the pH value of the solution and promote the crystallization of mesalamine with an apparent density greater than or equal to 0.30 g/ml, c) heat the melamine-based mass to make it reflux and keep it under these conditions until a complete crystallization, d) cooling and separating the high density mesalamine obtained. |
| priorityDate | 2013-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 38.