http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2697684-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f2d3599fb8f8f479dba95ca9bb504884 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4985 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4985 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 2014-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bbdfec380a881f4a415806f05f855f89 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fc1ec6db7625a06564cea659824430c0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_341b0921ff433315a428830cc911678e |
| publicationDate | 2019-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2697684-T3 |
| titleOfInvention | Derivatives of 4-amino-6-phenyl-5,6-dihydroimidazo [1,5 a] pyrazine as inhibitors of beta-secretase (BACE) |
| abstract | A compound of formula (I) ** Formula ** or a stereoisomeric form thereof, wherein R is selected from the group of hydrogen; halo; -CN; C 1-4 alkyl optionally substituted by one or more substituents, each of which is independently selected from halo, -CN and C 1-4 alkyl; C 1-4 alkyl optionally substituted by one or more substituents, each of which is independently selected from halo and C 1-4 alkyl; and - (CH2) m-NRx (C = O) Ry, where m is an integer selected from the group of 0, 1, 2 and 3, Rx is selected from H and C1-4alkyl and Ry is C1-4alkyl; R1 is selected from the group of hydrogen; halo; C1-4 alkyl optionally substituted by one or more halo substituents; -C 1-4 alkyl (C 3-7 cycloalkyl); and C 3-7 cycloalkyl; R 2 is selected from the C 1-4 alkyl group optionally substituted by one or more substituents, each of which is independently selected from fluoro and C 1-4 alkyl; and C 3-7 cycloalkyl; R3 is in each instance a halo substituent independently selected; n is an integer that is selected from 1 and 2; R4 is selected from (a) and (b): (a) (b) ** Formula ** wherein R5 and R6 are each independently selected from the aryl and heteroaryl group, each of which may optionally be substituted by one or more substituents each independently selected from the group of halo, -CN, C 1-4 alkyl optionally substituted by one or more halo substituents and C 1-4 alkyl optionally substituted by one or more halo substituents; where aryl is phenyl; wherein heteroaryl is a 5-membered aromatic heterocycle that is selected from the group consisting of oxazole and pyrazole; or is a 6-membered aromatic heterocycle that is selected from the group consisting of pyridinyl, pyrimidinyl and pyrazinyl; or a solvate or a pharmaceutically acceptable addition salt thereof. |
| priorityDate | 2013-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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