| abstract |
Ionizable lipid compound of formula I: ** Formula ** in which ~ n and m are independently 1, 2, 3 or 4; R1 and R2 are independently C10-18 alkyl or C12-18 alkenyl; X is -CH2-, S, O or is absent; L is C1-4 alkylene, -S-C1-4 alkylene, -O-C1-4 alkylene, -OC (O) -C 1-4 alkylene, -S (O) 2-C1-4 alkylene, or represents or a pharmaceutically acceptable salt form thereof, further characterized by being nym 2, or being X absent and being L or representing or being X -CH2- and being L-S-C1-4 alkylene, -S (O) 2-C1 alkylene -4, or -OC (O) -C 1-4 alkylene, or be XS, or be R1 and R2 each C10-18 alkyl. |