| abstract |
A peptide-antisense conjugate for the treatment of a certain disease condition, comprising an antisense oligomer of morpholino phosphorodiamidate directed against a gene whose expression is associated with the disease condition determined of a specific target tissue, and covalently linked thereto, by an XB bond, a cell penetration peptide having a sequence of (RXRRBR) 2, where R is arginine; B is β-alanine; and X is independently a neutral linear amino acid -C (O) - (CH2) n-NH-, where n is 4-6, where the cell penetration peptide selectively locates the antisense oligomer in the target tissue. |