| abstract |
Compound of the general formula (2.2) ** Formula ** in which Q refers to -C 1-8 aliphatic, -aryl, -C 1-8 aliphatic-aryl, -heteroaryl, -C (> = O) -heteroaryl or -C (> = NH) -heteroaryl; R1 refers to -CH3; R2 refers to -H or -CH3; or R1 and R2 together form a ring and refer to - (CH2) 3-4-; X refers to -O- or -NRA-; RA refers to -H or -aliphatic C1-8; RB refers to -C (> = O) -C3-8-arylcycloaliphatic, -C (> = O) -C3-8-heteroarylcycloaliphatic, -C (> = O) C1-8 NH-aliphatic, -S (> = O) 1-2-C1-8 aliphatic, -S (> = O) 1-2-aryl, -S (> = O) 1-2-heteroaryl, -S (> = O) 1-2 -C1-8-aryl aliphatic, -S (> = O) 1-2-C1-8-aliphatic-heteroaryl, -S (> = O) 1-2-C3-8-aryl cycloaliphatic or -S (> = O ) C3-8-heteroaryl 1-2-cycloaliphatic; or RA and RB together form a ring and refer to - (CH2) 3-4-; RC refers to -H, -F, -Cl, -Br, -I, -CN, -NO2, -CF3, -OH or -OCH3; and n refers to 0, 1, 2, 3 or 4; wherein "Aliphatic" is in each case a branched or unbranched, saturated or mono- or polyunsaturated hydrocarbon moiety, unsubstituted or substituted once or several times; "Cycloaliphatic" is in each case a mono- or multicyclic, alicyclic, saturated or mono- or polyunsaturated hydrocarbon moiety, unsubstituted or substituted once or several times, whose number of ring carbon atoms is preferably in the indicated range (it is ie, cycloaliphatic "C3-8" preferably has 3, 4, 5, 6, 7 or 8 ring carbon atoms); one or two carbon atoms being independently substituted for each other by a heteroatom S, N or O; wherein with respect to "aliphatic" and "cycloaliphatic" is meant by "substituted once or several times" the single or multiple replacement of one or more hydrogen atoms, for example single, double, triple or complete replacement, by selected substituents independently of each other from the group consisting of -F, -Cl, -Br, -I, -CN, -NO2, -CHO,> = O, -R0, -C (> = O) R0, -C (> = O ) H, -C (> = O) OH, -C (> = O) OR0, -C (> = O) NH2, -C (> = O) NHR0, -C (> = O) N (R0) 2, -OH, -OR0, -OC (> = O) H, -OC (> = O) R0, -OC (> = O) OR0, -OC (> = O) NHR0, -OC (> = O ) N (R0) 2, -SH, -SR0, -SO3H, -S (> = O) 1-2-R0, -S (> = O) 1-2NH2, -NH2, -NHR0, -N (R0 ) 2, -N + (R0) 3, -N + (R0) 2O-, -NHC (> = O) R0, -NHC (> = O) OR0, -NHC (> = O) NH2, -NHC (> = O) -NHR0, -NH-C (> = O) N (R0) 2, -Si (R0) 3 and -PO (OR0) 2; where R0 refers in each case independently to -C1-8 aliphatic, C3-12 -cycloaliphatic, -aryl, -heteroaryl, -C1-12 -aliphatic-C3-12 -aliphatic, -C1-8 -aliphatic, -C1-aliphatic -8-heteroaryl, -C3-8-cycloaliphatic C1-8, -cycloaliphatic C3-8-aryl or cycloaliphatic C3-8-heteroaryl; "aryl" in each case independently refers to a carbocyclic ring system with at least one aromatic ring, but without heteroatoms in this ring, the aryl moieties may be condensed where appropriate with other saturated, (partially) unsaturated ring systems or aromatic and each unsubstituted or substituted aryl moiety may be present once or several times, the aryl substituents being the same or different and being able to be in any discretionary and possible position of the aryl; "heteroaryl" refers to a cyclic aromatic moiety of 5, 6 or 7 members, containing 1, 2, 3, 4 or 5 heteroatoms, wherein the heteroatoms are the same or different nitrogen, oxygen or sulfur, and the heterocycle can be unsubstituted or substituted once or several times; it may be the same or different substituents in the heterocycle substitution and may be in any discretionary and possible position of the heteroaryl; and the heterocycle may also be part of a bi- or polycyclic system; understood in relation to "aryl" and "heteroaryl" by "substituted once or several times" the single or multiple substitution of one or more hydrogen atoms of the ring system by substituents selected from the group consisting of -F, -Cl, -Br , -I, -CN, -NO2, -CHO,> = O, -R0, -C (> = O) R0, -C (> = O) H, -C (> = O) OH, -C ( > = O) OR0, -C (> = O) NH2, -C (> = O) NHR0, -C (> = O) -N (R0) 2, -OH, -O (CH2) 1-2O- , -OR0, -OC (> = O) H, -OC (> = O) R0, -OC (> = O) OR0, -OC (> = O) NHR0, -OC (> = O) N (R0 ) 2, -SH, -SR0, -SO3H, -S (> = O) 1-2-R0, -S (> = O) 1-2NH2, -NH2, -NHR0, -N (R0) 2, - N + (R0) 3, -N + (R0) 2O-, -NHC (> = O) R0, -NHC (> = O) OR0, -NH- C (> = O) NH2, -NHC (> = O) NHR0, -NHC (> = O) N (R0) 2, -Si (R0) 3 or -PO (OR0) 2; the ring atoms of N may be oxidized in each case, if necessary; where R0 refers in each case independently to -C1-8 aliphatic, C3-12 -cycloaliphatic, -aryl, -heteroaryl, -C1-12 -aliphatic-C3-12 -aliphatic, -C1-8 -aliphatic, -C1-aliphatic -8-heteroaryl, -C3-8-cycloaliphatic C1-8, -cycloaliphatic C3-8-aryl or cycloaliphatic C3-8-heteroaryl; in the form of a single stereoisomer or mixture thereof, of the free compounds and / or their physiologically compatible salts. |