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publicationDate 2018-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber ES-2694050-T3
titleOfInvention Pharmaceutical composition including 5- {4- (aminosulfonyl) phenyl} -2,2-dimethyl-4- (3-fluorophenyl) -3 (2H) -furanone and capsule formulation including the pharmaceutical composition
abstract An anti-inflammatory pharmaceutical composition comprising (i) the compound of formula 1: ** Formula ** or a pharmaceutically acceptable salt thereof having a particle diameter of 50% volume (d (0.5)) of 3 μm a 9 μm measured by laser diffraction, (ii) a pharmaceutically acceptable diluent, and (iii) a pharmaceutically acceptable lubricant, wherein the compound of formula 1 exists in crystalline form A which has the results of X-ray diffraction analysis with radiation of Cu shown in table 1 and a differential scanning calorimetry (DSC) profile obtainable by heating at a rate of 10 ° C / min from 25 ° C to 220 ° C, said DSC profile having a peak in a range from 175.62 ° C to 178.35 ° C : ** Table ** or where the compound of formula 1 exists in the crystalline form G which has the results of X-ray diffraction analysis with Cu radiation shown in table 2 and a differential scanning calorimetry profile (D SC) obtainable by heating at a rate of 10 ° C / min from 25 ° C to 220 ° C, said DSC profile having a peak in a range from 181.06 ° C to 186.16 ° C: ** Table ** or where the compound of formula 1 exists in a mixture of crystalline form A and crystalline form G.
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